Document Detail

Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles.
MedLine Citation:
PMID:  15204749     Owner:  NLM     Status:  MEDLINE    
Twelve mildly asthmatic and four healthy adults were exposed to filtered air (FA) and concentrated ambient coarse particles (CCP) supplied to a whole-body exposure chamber via a coarse particle concentrator with 15 parallel virtual impactors. Exposures were conducted in a Los Angeles suburb with high levels of motor-vehicle pollution and lasted 2 h with intermittent exercise. Mean CCP concentration was 157 microg/m(3) (range: 56-218 microg/m(3)) measured by continuous monitoring with a tapered-element oscillating microbalance (TEOM). On average, 80% of mass was coarse (2.5-10 microm aerodynamic diameter) and the rest <2.5 microm. Relative to FA, CCP exposure did not significantly alter respiratory symptoms, spirometry, arterial oxygen saturation, or airway inflammation according to exhaled nitric oxide and total and differential cell counts of induced sputum. After CCP exposure, Holter electrocardiograms showed small (p <.05) increases in heart rate and decreases in heart-rate variability, which were larger in healthy than in asthmatic subjects. Cardiac ectopy did not increase. In conclusion, acute exposure to elevated concentrations of ambient coarse particles elicited no obvious pulmonary effects but appeared to alter the autonomic nervous system of the heart in adult volunteers.
Henry Gong; William S Linn; Sheryl L Terrell; Kenneth W Clark; Michael D Geller; Karen R Anderson; Wayne E Cascio; Constantinos Sioutas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Inhalation toxicology     Volume:  16     ISSN:  0895-8378     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-08-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-43     Citation Subset:  IM    
University of Southern California Keck School of Medicine, Los Angeles, USA.
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MeSH Terms
Air Pollution / adverse effects*
Asthma / physiopathology*
Atmosphere Exposure Chambers
Electrocardiography, Ambulatory
Heart Rate*
Inhalation Exposure / adverse effects*
Los Angeles
Middle Aged
Oxygen / blood
Particle Size
Sputum / cytology
Suburban Population
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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