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Altered gene expression in umbilical cord mononuclear cells in preterm infants with periventricular leukomalacia.
MedLine Citation:
PMID:  20932694     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: Periventricular leukomalacia (PVL) is one of the most important causes of adverse outcome of preterm infants. We hypothesized that inflammatory or some other specific pathways will have been activated at birth in preterm infants who later develop PVL. The aim of this study is to examine the difference in mRNA expression in umbilical cord blood according to the presence or absence of PVL.
METHODS: A total of 61 umbilical cord blood samples were collected from preterm infants with gestational age less than 33 weeks together with the patients' medical information during perinatal period. RNA expression patterns in the collected cord bloods were analyzed by microarray. On the basis of cranial ultrasonography and brain MRI examination, 3 infants (4.9%) were diagnosed as cystic PVL and selected as the subjects. Five patients who showed similar perinatal factors to those of infants with PVL but did not show PVL were selected as the normal control.
RESULTS: Five of the 15 up-regulated genes are coding ribosomal proteins, and another encodes a translation elongation factor. Three of the 7 down-regulated genes encode proteins that may be related to immune response and/or inflammation.
CONCLUSIONS: Up-regulation of the ribosomal proteins may indicate an activation of lymphocytes during the fetal period.
Authors:
Akihisa Okumura; Toshiyuki Yamamoto; Hiroyuki Kidokoro; Toru Kato; Tetsuo Kubota; Hiromichi Shoji; Hiroaki Sato; Keiko Shimojima; Toshiaki Shimizu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-06
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  665-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Juntendo University Faculty of Medicine, Japan. okumura@juntendo.ac.jp
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