| Altered gene expression in lymphocytes of patients with normal-tension glaucoma. | |
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MedLine Citation:
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PMID: 11262608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In glaucoma there is a loss of retinal ganglion cells. There is evidence that this loss can occur by apoptosis. The signal transduction leading to retinal ganglion cell apoptosis in glaucoma is not yet clear. The present study compares the gene expression in lymphocytes of normal tension glaucoma patients (NTG-patients) with the one of healthy controls. METHODS: Subtractive hybridization was used to compare mRNA in lymphocytes of six vasospastic NTG-patients with six age and sex matched healthy subjects. RESULTS: Genes coding for p53-protein, NTP (neural thread protein) and 20 S proteasome subunit XAPC7 were overexpressed, whereas those coding for XPGC (Xeroderma pigmentosum gene), the survivin protein as well as one type of ABC transport protein were underexpressed. CONCLUSION: In comparison to healthy controls, patients with vasospastic NTG seem to over- as well as under-express certain genes in their lymphocytes. |
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Authors:
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O Golubnitschaja-Labudova; R Liu; C Decker; P Zhu; I O Haefliger; J Flammer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Current eye research Volume: 21 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-03-23 Completed Date: 2001-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 867-76 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Basel, Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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genetics Adult Aged Amino Acid Sequence Base Sequence Cysteine Endopeptidases / genetics DNA-Binding Proteins / genetics Endonucleases Eye Proteins / genetics* Female Gene Expression Gene Expression Profiling Glaucoma, Open-Angle / metabolism* Humans In Situ Hybridization Lymphocytes / metabolism* Male Microtubule-Associated Proteins* Middle Aged Molecular Sequence Data Neoplasm Proteins Nerve Tissue Proteins / genetics Nuclear Proteins Proteins / genetics RNA, Messenger / metabolism* Transcription Factors Tumor Suppressor Protein p53 / genetics Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/AD7c-NTP; 0/ATP-Binding Cassette Transporters; 0/BIRC5 protein, human; 0/DNA excision repair protein ERCC-5; 0/DNA-Binding Proteins; 0/Eye Proteins; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Proteins; 0/RNA, Messenger; 0/Transcription Factors; 0/Tumor Suppressor Protein p53; EC 3.1.-/Endonucleases; EC 3.4.22.-/Cysteine Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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