Document Detail

Altered function of pulmonary surfactant in fatty acid lung injury.
MedLine Citation:
PMID:  2246164     Owner:  NLM     Status:  MEDLINE    
To determine whether acute fatty acid lung injury impairs pulmonary surfactant function, we studied anesthetized ventilated rabbits given oleic acid (55 mg/kg iv, n = 11) or an equivalent volume of saline (n = 8). Measurements of pulmonary mechanics indicated a decrease in dynamic compliance within 5 min of injury and a decrease in lung volume that was disproportionately large at low pressures, consistent with diminished surfactant activity in vivo. Bronchoalveolar lavage fluid obtained 1 h after injury had significantly increased erythrocytes and total leukocytes, largely polymorphonuclear cells. The phospholipid content and composition of the cell-free fraction had only minor changes from those of controls, but the protein content was increased 35-fold. Measurements of lavage surface activity in vitro showed an increase in average minimum surface tension from 1.3 +/- 0.4 (SE) dyn/cm in controls to 20.2 +/- 3.9 dyn/cm in injured animals. The alterations in static pressure-volume curves and decrease in lavage surface activity suggest a severe alteration of surfactant function in this form of lung injury that occurs despite the presence of normal amounts of surfactant phospholipids.
S B Hall; R H Notter; R J Smith; R W Hyde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1143-9     Citation Subset:  IM    
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642.
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MeSH Terms
Blood Gas Analysis
Bronchoalveolar Lavage Fluid / chemistry
Fatty Acids, Nonesterified / toxicity*
Lung / pathology
Lung Compliance / physiology
Neutrophils / physiology
Phosphatidylcholines / metabolism
Phospholipids / analysis
Pulmonary Surfactants / physiology*
Respiratory Distress Syndrome, Adult / chemically induced,  physiopathology*
Respiratory Function Tests
Surface Tension
Grant Support
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Phosphatidylcholines; 0/Phospholipids; 0/Pulmonary Surfactants

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