Document Detail


Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease.
MedLine Citation:
PMID:  12376361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deterioration of pulmonary surfactant function has been reported in interstitial lung disease; however, the molecular basis is presently unclear. We analyzed fatty acid (FA) profiles of several surfactant phospholipid classes isolated from large-surfactant aggregates of patients with idiopathic pulmonary fibrosis (IPF; n = 12), hypersensitivity pneumonitis (n = 5), and sarcoidosis (n = 12). Eight healthy individuals served as controls. The relative content of palmitic acid in phosphatidylcholine was significantly reduced in IPF (66.8 +/- 2.5%; means +/- SE; P < 0.01) but not in hypersensitivity pneumonitis (78.5 +/- 1.8%) and sarcoidosis (78.2 +/- 3.1%; control 80.1 +/- 0.7%). In addition, the phosphatidylglycerol FA profile was significantly altered in the IPF patients, with a lower relative content of its major FA, oleic acid, at the expense of saturated FA. In the phosphatidylcholine class, a significant correlation between the impairment of biophysical surfactant function and decreased percentages of palmitic acid was noted. We conclude that significant alterations in the FA profile of pulmonary surfactant phospholipids occur predominantly in IPF and may contribute to the disturbances of alveolar surface activity in this disease.
Authors:
R Schmidt; U Meier; P Markart; F Grimminger; H G Velcovsky; H Morr; W Seeger; A Günther
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  283     ISSN:  1040-0605     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-11     Completed Date:  2002-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L1079-85     Citation Subset:  IM    
Affiliation:
Medizinische Klinik II, Zentrum für Innere Medizin, Justus Liebig University, D-35392 Giessen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Cell Count
Fatty Acids / analysis*
Female
Humans
Lung Diseases, Interstitial / pathology,  physiopathology*
Male
Middle Aged
Palmitic Acid / analysis
Phospholipids / chemistry*,  isolation & purification
Pulmonary Surfactants / chemistry*
Reference Values
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Pulmonary Surfactants; 57-10-3/Palmitic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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