Document Detail


Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson disease.
MedLine Citation:
PMID:  16563567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutamatergic pathways play a key role in the functional organization of neuronal circuits involved in Parkinson disease (PD). Recently, three vesicular glutamate transporters (VGLUT1-3) were identified. VGLUT1 and VGLUT2 are responsible for the uploading of glutamate into synaptic vesicles and are the first specific markers of glutamatergic neurons available. Here, we analyzed the expression of VGLUT1 and VGLUT2 in autopsy tissues of PD patients and matched controls using Western blot and immunoautoradiography. VGLUT1 and VGLUT2 expression was increased in the Parkinsonian putamen by 24% and 29%, respectively (p<0.01). In contrast, only VGLUT1 was dramatically decreased in the prefrontal and temporal cortex of PD patients (approximately 50%, p<0.01 and p<0.001, respectively). These findings demonstrate the existence of profound alterations of glutamatergic transmission in PD, which are likely to contribute to the motor and cognitive impairments associated with the disease, and should thus be taken into account in the treatment of PD.
Authors:
Alireza Kashani; Catalina Betancur; Bruno Giros; Etienne Hirsch; Salah El Mestikawy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-24
Journal Detail:
Title:  Neurobiology of aging     Volume:  28     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-03-22     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-78     Citation Subset:  IM    
Affiliation:
INSERM U513, Faculté de Médecine, Université Paris XII, 8 rue du Général Sarrail, 94010 Créteil Cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Autoradiography / methods
Blotting, Western / methods
Brain / metabolism
Case-Control Studies
Female
Gene Expression Regulation / physiology*
Humans
Male
Middle Aged
Nerve Tissue Proteins / metabolism
Parkinson Disease / metabolism*,  pathology
Postmortem Changes
Vesicular Glutamate Transport Protein 1 / metabolism*
Vesicular Glutamate Transport Protein 2 / metabolism*
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/SLC17A6 protein, human; 0/SLC17A7 protein, human; 0/Vesicular Glutamate Transport Protein 1; 0/Vesicular Glutamate Transport Protein 2
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