Document Detail


Altered expression of lymphocyte Il-2 receptors in burned patients.
MedLine Citation:
PMID:  3264348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impairment of T-cell function is a consistent observation in burned patients. Concomitant with this impairment is an increase in serum factors which inhibit interleukin-2-mediated T-cell functions. These factors are heat labile and do not behave like endotoxins. Nonetheless, treatment of burned patients with endotoxin-neutralizing regimens of polymyxin B reduces the levels of these factors, suggesting that they are generated in response to endotoxin exposure. In addition to factors which inhibit Il-2 responses burn serum contains increases of circulating soluble, cell-free Il-2 receptors. However, the level of Il-2R is not altered by polymyxin B treatment and does not appear to be a direct result of endotoxin exposure. These observations suggest that multiple causes contribute to T-cell impairment in burned patients.
Authors:
G X Xiao; R K Chopra; W H Adler; A Munster; R A Winchurch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of trauma     Volume:  28     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-19     Completed Date:  1989-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1669-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
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MeSH Terms
Descriptor/Qualifier:
Adult
Burns / drug therapy,  immunology*
Endotoxins / blood
Humans
Lymphocyte Activation
Polymyxin B / therapeutic use
Receptors, Interleukin-2 / analysis*
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
GM 26235/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Receptors, Interleukin-2; 1404-26-8/Polymyxin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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