| Altered expression of lymphocyte Il-2 receptors in burned patients. | |
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MedLine Citation:
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PMID: 3264348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impairment of T-cell function is a consistent observation in burned patients. Concomitant with this impairment is an increase in serum factors which inhibit interleukin-2-mediated T-cell functions. These factors are heat labile and do not behave like endotoxins. Nonetheless, treatment of burned patients with endotoxin-neutralizing regimens of polymyxin B reduces the levels of these factors, suggesting that they are generated in response to endotoxin exposure. In addition to factors which inhibit Il-2 responses burn serum contains increases of circulating soluble, cell-free Il-2 receptors. However, the level of Il-2R is not altered by polymyxin B treatment and does not appear to be a direct result of endotoxin exposure. These observations suggest that multiple causes contribute to T-cell impairment in burned patients. |
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Authors:
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G X Xiao; R K Chopra; W H Adler; A Munster; R A Winchurch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 28 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-19 Completed Date: 1989-01-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1669-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Burns / drug therapy, immunology* Endotoxins / blood Humans Lymphocyte Activation Polymyxin B / therapeutic use Receptors, Interleukin-2 / analysis* T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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GM 26235/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Receptors, Interleukin-2; 1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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