Document Detail

Altered expression of UVB-induced cytokines in human papillomavirus-immortalized epithelial cells.
MedLine Citation:
PMID:  18796714     Owner:  NLM     Status:  MEDLINE    
Keratinocytes can be induced to produce cytokines by exogenous stimuli, such as UVB, and dysregulation of this production has been described in various skin diseases, including cancer. In this study, we compared the effect of UVB on the secretion of several cytokines involved in inflammation by human keratinocytes immortalized or not with human papillomavirus (HPV)16 or HPV38 at the mRNA and protein levels. We show that expression of the HPV E6/E7 oncoproteins influences not only the basal cytokine secretion profile of keratinocytes, but also its modulation upon UVB irradiation. In particular, UVB upregulates interleukin (IL)-6, IL-8 and transforming growth factor (TGF)-beta in HPV-immortalized cells to a higher extent than in control keratinocytes. Moreover, expression of other pro-inflammatory molecules such as S100A8/9 and interferon (IFN)-kappa was downregulated in HPV-immortalized cells. These data support the functional similarity between HPV16 and 38, and suggest an active role of these viruses in modulation of the inflammatory process.
Valentina Dell'oste; Barbara Azzimonti; Michele Mondini; Marco De Andrea; Cinzia Borgogna; Riccardo Mesturini; Rosita Accardi; Massimo Tommasino; Santo Landolfo; Umberto Dianzani; Marisa Gariglio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  89     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2461-6     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Medical School of Novara, Via Solaroli 17, 28100 Novara, Italy.
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MeSH Terms
Betapapillomavirus* / genetics,  metabolism,  pathogenicity
Cell Line, Transformed
Cell Transformation, Viral*
Cytokines / genetics,  metabolism*,  radiation effects
Gene Expression Regulation*
Human papillomavirus 16* / genetics,  metabolism,  pathogenicity
Keratinocytes* / immunology,  virology
Oncogene Proteins, Viral / genetics,  metabolism
Papillomavirus E7 Proteins / genetics,  metabolism
RNA, Messenger / genetics,  metabolism,  radiation effects
Repressor Proteins / genetics,  metabolism
Ultraviolet Rays*
Reg. No./Substance:
0/Cytokines; 0/E6 protein, Human papillomavirus type 16; 0/Oncogene Proteins, Viral; 0/Papillomavirus E7 Proteins; 0/RNA, Messenger; 0/Repressor Proteins; 0/oncogene protein E7, Human papillomavirus type 16

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