| Altered dystrophin expression in the right atrium of a patient after Fontan procedure with atrial flutter. | |
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MedLine Citation:
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PMID: 15546999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Underlying mechanisms in the development of atrial flutter or intra-atrial re-entry tachycardia in patients with structural cardiac abnormalities remain poorly defined. The right atrial myocardium from two patients with congenital heart disease was evaluated, of whom one presented with severe right atrial dilation and arrhythmia and the other with a normal right atrium, to assess whether increased right atrial pressure and volume overload give rise to sarcolemmal alteration. N-terminus dystrophin staining in the atrium from the patient who had undergone a Fontan procedure showed a normally distributed but significantly reduced staining signal compared with the second patient. This is the first report that patients with severe right atrial dilation and atrial flutter have marked reduction in atrial dystrophin expression. |
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Authors:
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C J McMahon; M Vatta; C D Fraser; J A Towbin; A C Chang |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 90 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-01-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: e65 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics (Cardiology), Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin, MC 19345-C, Houston, Texas 77030, USA. cmcmahon@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Flutter
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metabolism Child Dilatation, Pathologic Dystrophin / analysis* Fontan Procedure* Heart Atria / chemistry, pathology Humans Male Myocardium / chemistry*, pathology Postoperative Complications / etiology Tricuspid Atresia / surgery* |
| Chemical | |
Reg. No./Substance:
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0/Dystrophin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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