Document Detail

Altered dystrophin expression in the right atrium of a patient after Fontan procedure with atrial flutter.
MedLine Citation:
PMID:  15546999     Owner:  NLM     Status:  MEDLINE    
Underlying mechanisms in the development of atrial flutter or intra-atrial re-entry tachycardia in patients with structural cardiac abnormalities remain poorly defined. The right atrial myocardium from two patients with congenital heart disease was evaluated, of whom one presented with severe right atrial dilation and arrhythmia and the other with a normal right atrium, to assess whether increased right atrial pressure and volume overload give rise to sarcolemmal alteration. N-terminus dystrophin staining in the atrium from the patient who had undergone a Fontan procedure showed a normally distributed but significantly reduced staining signal compared with the second patient. This is the first report that patients with severe right atrial dilation and atrial flutter have marked reduction in atrial dystrophin expression.
C J McMahon; M Vatta; C D Fraser; J A Towbin; A C Chang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  90     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-01-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  e65     Citation Subset:  AIM; IM    
Department of Pediatrics (Cardiology), Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin, MC 19345-C, Houston, Texas 77030, USA.
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MeSH Terms
Atrial Flutter / metabolism
Dilatation, Pathologic
Dystrophin / analysis*
Fontan Procedure*
Heart Atria / chemistry,  pathology
Myocardium / chemistry*,  pathology
Postoperative Complications / etiology
Tricuspid Atresia / surgery*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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