| Altered dynamics of alpha-fetoprotein production following pyridoxine and adenosine 5'-triphosphate administration to cirrhotic patients with or without primary hepatomas and to liver-injured and hepatoma-bearing rats. | |
| | |
MedLine Citation:
|
PMID: 6173868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In 12 cirrhotic patients who developed primary hepatocellular carcinomas during long-term follow-up, surveillance by frequent serum alpha-fetoprotein (AFP) measurements was not useful for their earlier detection. Difficulty was encountered in deciding whether or not hepatomas had already developed in cirrhotic patients with serum AFP levels over 200 ng/ml. Simultaneous injections of pyridoxine and adenosine 5'-triphosphate (ATP) resulted insignificant decreases of elevated serum AFP levels in carbon tetrachloride (CCl4)-injured rats but in 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatoma-bearing rats. On clinical application of this procedure, it was found that cirrhotic patients without hepatomas could be differentiated from those with primary hepatomas since in the former a clear reduction of AFP levels following the administration of pyridoxine and ATP took place. This may be a new approach to the earlier diagnosis of primary hepatomas in cirrhotic patients with elevated serum AFP levels. |
| | |
Authors:
|
A Watanabe; H Nagashima |
Related Documents
:
|
10823658 - Appearance of extracellular glutathione peroxidase (egpx) in the ascite fluid of casein... 1296178 - Tfx-polfa in the treatment of transplantable morris 5123 hepatoma in buffalo rats. 6091938 - Induction of a distinct nuclear poly(a) polymerase and the production of anti-tumor pol... 165018 - Hexokinase isozyme pattern in ccl(4)-injured rat liver. 147038 - An "in vitro" system for the study of rat spermatogonial proliferative control. 15233768 - Intraocular delivery of bdnf following visual cortex lesion upregulates cytosolic branc... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Volume: 2 ISSN: 0167-1618 ISO Abbreviation: Oncodev. Biol. Med. Publication Date: 1981 |
Date Detail:
|
Created Date: 1982-04-12 Completed Date: 1982-04-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8100446 Medline TA: Oncodev Biol Med Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 313-21 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
pharmacology Animals Carbon Tetrachloride Poisoning / metabolism Carcinoma, Hepatocellular / diagnosis, metabolism* Humans Liver Cirrhosis / metabolism Liver Neoplasms / metabolism* Liver Neoplasms, Experimental / metabolism* Liver Regeneration Male Pyridoxine / pharmacology Rats alpha-Fetoproteins / biosynthesis* |
| Chemical | |
Reg. No./Substance:
|
0/alpha-Fetoproteins; 56-65-5/Adenosine Triphosphate; 65-23-6/Pyridoxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pseudo-fracture of pacemaker lead due to securing suture: a case report.
Next Document: Similarity of hydrophobic properties of alpha-fetoprotein and albumin.