Document Detail

Altered dopamine function in pathological gambling.
MedLine Citation:
PMID:  9089839     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The possibility that monoaminergic neurotransmission is altered in pathological gambling was examined. METHODS: Monoamines and their metabolites were measured in CSF obtained at level L4-5 from ten pathological gamblers and seven controls. RESULTS: A decrease in dopamine and an increase in 3,4-dihydroxyphenylacetic acid and homovanilic acid was found. Noradrenaline and its metabolite 3-methoxy-4-hydroxyphenylglycol was also increased but 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged. CONCLUSION: It is suggested that the function of the dopaminergic system, possibly mediating positive and negative reward, and the noradrenergic system, possibly mediating selective attention, is changed in pathological gambling.
C Bergh; T Eklund; P Södersten; C Nordin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  27     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-27     Completed Date:  1997-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-5     Citation Subset:  IM    
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge, Sweden.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid
Attention / physiology
Brain / physiopathology
Dopamine / physiology*
Gambling / psychology*
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Norepinephrine / physiology
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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