Document Detail


Altered dopamine function in pathological gambling.
MedLine Citation:
PMID:  9089839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The possibility that monoaminergic neurotransmission is altered in pathological gambling was examined. METHODS: Monoamines and their metabolites were measured in CSF obtained at level L4-5 from ten pathological gamblers and seven controls. RESULTS: A decrease in dopamine and an increase in 3,4-dihydroxyphenylacetic acid and homovanilic acid was found. Noradrenaline and its metabolite 3-methoxy-4-hydroxyphenylglycol was also increased but 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged. CONCLUSION: It is suggested that the function of the dopaminergic system, possibly mediating positive and negative reward, and the noradrenergic system, possibly mediating selective attention, is changed in pathological gambling.
Authors:
C Bergh; T Eklund; P Södersten; C Nordin
Related Documents :
1905599 - Glycosaminoglycans in the synovial fluids of patients with juvenile rheumatoid arthritis.
1321419 - Catecholamines and vitiligo.
2302019 - Septic encephalopathy. evidence for altered phenylalanine metabolism and comparison wit...
9167049 - Respiratory tract lining fluid antioxidants: the first line of defence against gaseous ...
7770779 - Chemical characterization of a family of brain lipids that induce sleep.
9537289 - Catalase and oviductal fluid reverse the decreased motility of bovine sperm in culture ...
1385849 - Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney ...
8119779 - Comparison between the effect of butyric acid and its prodrug pivaloyloxymethylbutyrate...
21491109 - Characterization of non-enzymatic acylation of amino or thiol groups of bionucleophiles...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  27     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-27     Completed Date:  1997-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid
Attention / physiology
Brain / physiopathology
Dopamine / physiology*
Gambling / psychology*
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Motivation
Norepinephrine / physiology
Chemical
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in classification of suicide in England and Wales: time trends and associations with coroner...
Next Document:  Increased plasma concentrations of the 5-HT precursor amino acid tryptophan and other large neutral ...