Document Detail


Altered divalent ion metabolism in early renal failure: role of 1,25(OH)2D.
MedLine Citation:
PMID:  3839029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study evaluates the role of 1,25(OH)2D in the pathogenesis of abnormal mineral metabolism in patients with early renal failure (ERF). This was accomplished by examining the calcemic response to PTH and the handling of an oral phosphate load both before and after 6 weeks of therapy with 1,25(OH)2D. Twelve patients with ERF and six normal volunteers were studied. Patients with ERF as compared with normal subjects have low serum phosphate, low urinary calcium, low serum 1,25(OH)2D, and high plasma PTH and urinary cyclic AMP (cAMP). With EDTA infusion, an impaired calcemic response to PTH is observed in patients with ERF. The phosphate load test shows that these patients have an increased ability to excrete phosphate. After 1,25(OH)2D therapy a significant increase in serum phosphate, urinary calcium, and a decrease in urinary cAMP is observed only in ERF patients. In addition, the impaired calcemic response to PTH improves significantly, the renal handling of phosphate becomes normal, and the low baseline level of 1,25(OH)2D increases to normal. A significant correlation between levels of 1,25(OH)2D and creatinine clearance is observed in both patients and normals. In summary, the present data suggest that a mild deficiency of 1,25(OH)2D is present in ERF patients. The pathophysiological consequence of such a deficiency in patients with ERF may be important.
Authors:
L Wilson; A Felsenfeld; M K Drezner; F Llach
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  27     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-07-11     Completed Date:  1985-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Calcitriol / deficiency,  therapeutic use*
Calcium / metabolism
Cations, Divalent / metabolism
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic / drug therapy,  metabolism*,  physiopathology
Male
Middle Aged
Parathyroid Glands / physiopathology
Parathyroid Hormone / blood
Phosphates / metabolism
Vitamin D Deficiency / physiopathology
Chemical
Reg. No./Substance:
0/Cations, Divalent; 0/Parathyroid Hormone; 0/Phosphates; 32222-06-3/Calcitriol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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