| Altered distribution of caveolin-1 in early liver steatosis. | |
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MedLine Citation:
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PMID: 21250982 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Eur J Clin Invest 2011 ABSTRACT: Background Caveolin-1, the main structural protein of caveolae, is involved in cholesterol homoeostasis, transcytosis, endocytosis and signal transduction and thought to play an important role in lipidogenesis. Little is known about the pathophysiological role of caveolin-1 in nonalcoholic fatty liver disease (NAFLD), a condition frequently associated with the metabolic syndrome and characterized by abnormal accumulation of intrahepatic triglycerides with a potentially harmful risk of evolution to liver fibrosis, cirrhosis and hepatocellular carcinoma. Materials and methods Liver steatosis (micro/macrovesicular) was induced in adult rats fed a choline-deficient diet for 14 days and compared with a control normal diet. The expression and subcellular distribution of caveolin-1 was assessed using light and electron microscopy by immunohistochemical and immunocytochemical techniques and by Western blotting. Results Caveolin-1 was mainly associated with the hepatocyte basolateral plasma membrane. Fatty hepatocytes were characterized by a significant increase in the expression of caveolin-1 around and within the lipid droplets as well as in the inner membrane of mitochondria. Conclusions Our data suggest the involvement of caveolin-1 in the case of abnormal lipogenesis and mitochondrial function typical of steatotic hepatocytes in NAFLD. Addressing the role played by caveolin-1 in liver membranes in NAFLD may help future therapeutic choices in a frequent metabolic liver disease. |
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Authors:
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Maria Mastrodonato; Giuseppe Calamita; Roberta Rossi; Donatella Mentino; Leonilde Bonfrate; Piero Portincasa; Domenico Ferri; Giuseppa E Liquori |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-20 |
Journal Detail:
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Title: European journal of clinical investigation Volume: - ISSN: 1365-2362 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation. |
Affiliation:
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Department of Animal and Environmental Biology, "Aldo Moro" University, Bari, Italy Department of General and Environmental Physiology, "Aldo Moro" University, Bari, Italy Pathological Anatomy, Laboratory of Ultrastructural Pathology, "Aldo Moro" University, Bari, Italy Department of Internal Medicine and Public Medicine, "Aldo Moro" University, Bari, Italy. |
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