Document Detail


Altered disposition of vascular catecholamines in hypertensive (DOCA-salt) rats.
MedLine Citation:
PMID:  7418539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of norepinephrine (NE), dopamine (DA) and epinephrine (E) in the vasculature of hypertension (DOCA-SALT) and normotensive rats were determined by radioenzymatic assay. Significant decreases in the NE content of the mesenteric artery, renal artery and cardiac tissue from DOCA-Salt treated rats were found. In contrast the NE content of the inferior vena cava, abdominal aorta and mesenteric vein were not significantly decreased in the DOCA-Salt treated rats. There was no evidence of an altered disposition of DA and E in the vasculature of DOCA-Salt treated rats. The results of the study indicate that NE is selectively depleted in the cardiovascular system of this model of experimental hypertension and it is proposed that this property reflects different functional roles of individual elements of the vasculature in the DOCA-Salt hypertensive rat.
Authors:
G A Crabb; R J Head; J Hempstead; B A Berkowitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension     Volume:  2     ISSN:  0148-3927     ISO Abbreviation:  Clin Exp Hypertens     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7803060     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Desoxycorticosterone
Dopamine / metabolism*
Epinephrine / metabolism*
Hypertension / chemically induced,  metabolism*
Mesenteric Arteries / metabolism
Myocardium / metabolism
Norepinephrine / metabolism*
Rats
Renal Artery / metabolism
Sodium Chloride
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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