Document Detail

Altered diaphragm contractile properties with controlled mechanical ventilation.
MedLine Citation:
PMID:  12015377     Owner:  NLM     Status:  MEDLINE    
This study shows that, over time, diaphragm inactivity with controlled mechanical ventilation (CMV) decreases diaphragm force and produces myofibril damage contributing to the reduced force. We measured in vivo and in vitro diaphragm contractile and morphological properties in 30 sedated rabbits grouped (n = 6) as follows: 1 or 3 days of CMV, 1 or 3 days of 0 cmH(2)O continuous positive airway pressure, and control. The CMV rate was set sufficient to suppress diaphragm electrical activity. Compared with the control group, phrenic-stimulated maximum transdiaphragmatic pressure did not decrease with continuous positive airway pressure but decreased to 63% after 1 day of CMV and to 49% after 3 days of CMV. The in vitro tetanic force decreased to 86% after 1 day of CMV and to 44% after 3 days of CMV. After 3 days of CMV, significant myofibril damage occurred in the diaphragm but not in the soleus. The decrease in tetanic force correlated with the volume density of abnormal myofibrils. We conclude that CMV had a detrimental effect on diaphragm contractile properties.
Catherine S H Sassoon; Vincent J Caiozzo; Albana Manka; Gary C Sieck
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-10-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2585-95     Citation Subset:  IM    
Department of Medicine, Veterans Affairs Long Beach Health Care System and University of California, Irvine, California 90822, USA.
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MeSH Terms
Anatomy, Cross-Sectional
Diaphragm / physiology*,  ultrastructure
Electric Stimulation
Isometric Contraction / physiology*
Muscle Fatigue / physiology
Muscle Fibers, Skeletal / enzymology,  ultrastructure
Muscle, Skeletal / ultrastructure
Myosins / metabolism
Phrenic Nerve / physiology
Positive-Pressure Respiration
Protein Isoforms / metabolism
Reference Values
Respiration, Artificial*
Succinate Dehydrogenase / metabolism
Time Factors
Grant Support
Reg. No./Substance:
0/Protein Isoforms; EC Dehydrogenase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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