| Altered cytokine activities are related to the suppression of synthesis of normal immunoglobulin in multiple myeloma. | |
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MedLine Citation:
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PMID: 2643860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The content of peripheral blood B cells (B1+) was reduced in patients of multiple myeloma (MM) and not in those with benign monoclonal gammopathy (BMG) compared to normal donors (P less than 0.01). This observation correlated with the suppression of synthesis of normal immunoglobulin (Ig) in MM. Thus, cytokine activities regulating the proliferation of normal mature B cells, such as B cell stimulatory factor 1 (BSF-1)/interleukin 4 (IL-4), B cell growth inhibitory factor (BIF) and IL-2 in peripheral blood T cells, and IL-1 in peripheral blood adherent cells, were investigated in patients with BMG (n = 7) and MM (n = 28). All patients of MM having a marked suppression of synthesis of all other normal Ig, had significantly lower levels of BSF-1 activity and inversely higher levels of BIF activity than those of normal donors. However, patients with BMG having no suppression of synthesis of normal Ig had BSF-1 and BIF activities similar to normal donors. There was no significant difference in IL-1 and IL-2 activities between both normal donors and BMG versus MM patients. These data show that in MM altered cytokine activities correlate with suppression of synthesis of normal Ig. |
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Authors:
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M Kawano; K Iwato; H Asaoku; O Tanabe; H Tanaka; H Ishikawa; A Kuramoto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hematology Volume: 30 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-02-28 Completed Date: 1989-02-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 91-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Hiroshima University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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pathology Biological Factors / physiology* Cytokines Humans Immunoglobulins / biosynthesis* Interleukin-1 / metabolism Interleukin-2 / metabolism Lymphokines / metabolism Multiple Myeloma / blood*, metabolism, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors; 0/Cytokines; 0/Immunoglobulins; 0/Interleukin-1; 0/Interleukin-2; 0/Lymphokines; 0/lymphocyte proliferation potentiating factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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