Document Detail

Altered collagen expression in jugular veins in multiple sclerosis.
MedLine Citation:
PMID:  22770861     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Venous abnormalities have been associated with different neurological conditions, and the presence of a vascular involvement in multiple sclerosis (MS) has long been anticipated. In view of the recent debate regarding the existence of cerebral venous outflow impairment in MS due to abnormalities of the azygos or internal jugular veins (IJVs), we have studied the morphological and biological features of IJVs in MS patients.
METHODS: We examined (a) IJVs specimens from MS patients who underwent surgical reconstruction of the IJV and specimens of the great saphenous vein used for surgical reconstruction, (b) different vein specimens from an MS patient dead of an unrelated cause, and (c) autoptical and surgical IJV specimens from patients without MS. Collagen deposition was assessed by means of Sirius red staining followed by polarized light examination. The expression of collagen type I and III, cytoskeletal proteins (α-smooth muscle actin and smooth muscle myosin heavy chains), and inflammatory markers (CD3 and CD68) was investigated.
RESULTS: The extracranial veins of MS patients showed focal thickenings of the wall characterized by a prevailing yellow-green birefringence (corresponding to thin, loosely packed collagen fibers) correlated to a higher expression of type III collagen. No differences in cytoskeletal protein and inflammatory marker expression were observed.
DISCUSSION: The IJVs of MS patients presenting a focal thickening of the vein wall are characterized by the prevalence of loosely packed type III collagen fibers in the adventitia. Further studies are required to determine whether the observed venous alterations play a role in MS pathogenesis.
Matteo Coen; Erica Menegatti; Fabrizio Salvi; Francesco Mascoli; Paolo Zamboni; Giulio Gabbiani; Marie-Luce Bochaton-Piallat
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-05
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  22     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-28     Revised Date:  2014-03-24    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Actins / analysis
Aged, 80 and over
Antigens, CD / analysis
Antigens, CD3 / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Biological Markers / analysis
Case-Control Studies
Collagen Type I / analysis*
Collagen Type III / analysis*
Inflammation Mediators / analysis
Jugular Veins / chemistry*,  pathology
Microscopy, Polarization
Middle Aged
Multiple Sclerosis, Chronic Progressive / metabolism*,  pathology
Multiple Sclerosis, Relapsing-Remitting / metabolism*,  pathology
Myosin Heavy Chains / analysis
Staining and Labeling / methods
Reg. No./Substance:
0/ACTA2 protein, human; 0/Actins; 0/Antigens, CD; 0/Antigens, CD3; 0/Antigens, Differentiation, Myelomonocytic; 0/Biological Markers; 0/CD68 antigen, human; 0/Collagen Type I; 0/Collagen Type III; 0/Inflammation Mediators; EC Heavy Chains
Erratum In:
Cardiovasc Pathol. 2014 Mar-Apr;23(2):111

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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