| Altered cobalamin distribution in rat hepatomas and in the livers of rats treated with diethylnitrosamine. | |
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MedLine Citation:
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PMID: 195713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of cobalamin cofactors was investigated in the livers and tumors of rats bearing transplanted Morris 7777 or 7800 hepatomas, in the livers of rats treated with the hepatocarcinogen diethylnitrosamine, and in normal rats. There was a significant increase in the proportion of methylcobalamin both in livers and tumors from rat bearing the hepatomas 7777 and 7800 compared to the proportion of methylcobalamin in the livers of normal rats. The total cobalamin content of the hepatomas was significantly lower than that of host or control livers. Similarly, the total cobalamin content of the livers from the tumor-bearing rats was less than that in control animals. The administration to rats of an acute dose of diethylnitrosamine led to an 84% increase in the hepatic concentration of methylcobalamin. Chronic administration of diethylnitrosamine slightly increased the hepatic methylcobalamin concentration, but this was not statistically significant. Liver weight was reduced, and the hepatic content of total cobalamin fell to 55% of that in control animals. |
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Authors:
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J C Linnell; E V Quadros; D M Matthews; H P Morris; L A Poirier |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 37 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-09-29 Completed Date: 1977-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2975-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / chemically induced, metabolism* Cobamides / metabolism, physiology Diethylnitrosamine / pharmacology* Female Liver / drug effects*, metabolism Liver Neoplasms / chemically induced, metabolism* Neoplasms, Experimental / chemically induced, metabolism Nitrosamines / pharmacology* Rats Vitamin B 12 / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cobamides; 0/Nitrosamines; 55-18-5/Diethylnitrosamine; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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