Document Detail

Altered clinical course of malignant melanoma in HIV-positive patients.
MedLine Citation:
PMID:  12056957     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the natural history of melanoma is different in patients who test positive for human immunodeficiency virus (HIV) compared with matched control subjects. DESIGN: Retrospective cohort analysis. SETTING: Ambulatory care at 2 university-affiliated medical centers. PATIENTS: Each HIV-positive melanoma patient (n = 17) was randomly matched with 2 HIV-negative patients (HIV status unknown, but without risk factors for HIV) based on the melanoma subtype, tumor thickness, Clark level, tumor location, and sex and age of the patient. MAIN OUTCOME MEASURES: Disease-free survival and overall survival of HIV-positive and HIV-negative melanoma patients were compared using a matched-pairs analysis. CD4 cell counts were recorded at the time of melanoma diagnosis and disease recurrence. RESULTS: Melanoma patients who were HIV positive had a significantly shorter disease-free survival (P =.03) and overall survival (P =.045) compared with HIV-negative melanoma patients by matched-pairs analysis. There was an inverse relationship between CD4 cell counts and time to first melanoma recurrence. CONCLUSIONS: The natural history of malignant melanoma in HIV-positive patients is more aggressive compared with matched HIV-negative melanoma patients. Altered immune response and comorbid disease may play a role in the poor clinical outcome of HIV-positive patients. These findings have important implications in the management of melanoma in the setting of HIV disease.
Lori K E Rodrigues; Barbara J Klencke; Kirsten Vin-Christian; Timothy G Berger; Richard I Crawford; James R Miller; Carlos M M Ferreira; Mehdi Nosrati; Mohammed Kashani-Sabet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  138     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-11     Completed Date:  2002-07-05     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-70     Citation Subset:  AIM; IM    
University of California, San Francisco, Melanoma Center, UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA.
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MeSH Terms
Age Distribution
Biopsy, Needle
Case-Control Studies
Cohort Studies
Disease Progression
Disease-Free Survival
HIV Seronegativity
HIV Seropositivity
Melanoma / mortality*,  pathology*,  physiopathology
Middle Aged
Neoplasm Staging
Reference Values
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Distribution
Skin Neoplasms / mortality*,  pathology*,  physiopathology
Statistics, Nonparametric
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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