Document Detail

Altered circadian rhythms of the stress hormone and melatonin response in lupus-prone MRL/MP-fas(Ipr) mice.
MedLine Citation:
PMID:  10882059     Owner:  NLM     Status:  MEDLINE    
The immune system interacts with the hypothalamo-pituitary-adrenal axis via so-called glucocorticoid increasing factors, which are produced by the immune system during immune reactions, causing an elevation of systemic glucocorticoid levels that contribute to preservation of the immune reactions specificities. Previous results from our laboratory had already shown an altered immuno-neuroendocrine dialogue via the hypothalamo-pituitary-adrenal axis in autoimmune disease-prone chicken and mouse strains. In the present study, we further investigated the altered glucocorticoid response via the hypothalamo-pituitary-adrenal axis in murine lupus. We established the circadian rhythms of corticosterone, dehydroepiandrosterone-sulfate, adrenocorticotropic hormone and melatonin, as well as the time response curves after injection of interleukin-1 of the first three parameters in normal SWISS and lupus-prone MRL/MP-fas(Ipr) mice. The results show that lupus-prone MRL/ MP-fas(Ipr) mice do not react appropriately to changes of the light/dark cycle, circadian melatonin rhythms seem to uncouple from the light/dark cycle, and plasma corticosterone levels are elevated during the resting phase. Diurnal changes of dehydroepiandrosterone-sulfate and adrenocorticotropic hormone were normal compared to healthy controls. These data indicate that MRL/ MP-fas(Ipr) mice not only show an altered glucocorticoid response mediated via the hypothalamo pituitary adrenal axis to IL-1, but are also affected by disturbances of corticosterone and melatonin circadian rhythms. Our findings may have implications for intrathymic T cell development and the emergence of autoimmune disease.
O Lechner; H Dietrich; A Oliveira dos Santos; G J Wiegers; S Schwarz; M Harbutz; M Herold; G Wick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autoimmunity     Volume:  14     ISSN:  0896-8411     ISO Abbreviation:  J. Autoimmun.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-17     Completed Date:  2000-10-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8812164     Medline TA:  J Autoimmun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  325-33     Citation Subset:  IM    
Institute for General and Experimental Pathology, Medical School, University of Innsbruck, Austria.
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MeSH Terms
Adrenal Glands / metabolism
Adrenocorticotropic Hormone / blood*
Corticosterone / biosynthesis,  blood*
Dehydroepiandrosterone Sulfate / blood*
Hypothalamo-Hypophyseal System / immunology,  physiopathology
Lupus Erythematosus, Systemic / blood,  immunology,  physiopathology*
Melatonin / blood*
Mice, Inbred MRL lpr
Pituitary-Adrenal System / immunology,  physiopathology
Sleep Disorders, Circadian Rhythm / blood*,  etiology,  immunology
Stress, Physiological / blood,  immunology,  physiopathology
Reg. No./Substance:
50-22-6/Corticosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 73-31-4/Melatonin; 9002-60-2/Adrenocorticotropic Hormone

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