Document Detail

Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: relationship with biogenic amine metabolism.
MedLine Citation:
PMID:  7694027     Owner:  NLM     Status:  MEDLINE    
To study the possible role of several amino acids on feeding in the anorexia of aging, we have measured plasma and cerebrospinal fluid (CSF) concentrations of 22 amino acids in 14 elderly persons with idiopathic anorexia and 10 healthy subjects with normal weight in a similar age range. Plasma and CSF amino acid concentrations and CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels were all measured by HPLC methods. Elderly anorectic subjects had significantly lower levels of glutamic acid but increased concentrations of glutamine in both plasma and CSF compared to controls. Likewise, a significant increase of histidine, threonine, alanine, arginine, valine, methionine, isoleucine, leucine, phenylalanine, tryptophan, ornithine and lysine was found in CSF, but not in plasma, from patients with anorexia. Besides, the CSF histidine/LNAA (large neutral amino acids) and tryptophan/LNAA ratios were elevated in anorectic patients as compared with controls of similar age. In addition, we found higher CSF concentrations of HVA and 5-HIAA, as well as a positive correlation between CSF LNAA and either HVA (r = 0.74, p = 0.002) or 5-HIAA (r = 0.61, p = 0.020) concentrations in elderly anorectics. CSF tryptophan correlated positively with 5-HIAA levels (r = 0.59, p = 0.026) and CSF tyrosine with HVA levels (r = 0.77, p = 0.002). Our results suggest that changes in the CSF concentration of amino acids could contribute to an increased biogenic amine metabolism in the central nervous system of elderly anorectic subjects, possibly increasing the synaptic liberation of biogenic amines involved in the appetite regulation.
M Martinez; F Arnalich; J J Vazquez; A Hernanz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  53     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-14     Completed Date:  1993-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1643-50     Citation Subset:  IM    
Department of Biochemistry, La Paz Hospital, Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Aging / blood,  cerebrospinal fluid*
Amino Acids / blood,  cerebrospinal fluid*
Anorexia / blood,  cerebrospinal fluid*,  drug therapy
Biogenic Amines / blood,  cerebrospinal fluid*
Body Weight / physiology
Homovanillic Acid / blood,  cerebrospinal fluid
Hydroxyindoleacetic Acid / blood,  cerebrospinal fluid
Leukocyte Count
Lymphocytes / cytology
Megestrol / therapeutic use
Serum Albumin / metabolism
Transferrin / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Amines; 0/Serum Albumin; 11096-37-0/Transferrin; 306-08-1/Homovanillic Acid; 3562-63-8/Megestrol; 54-16-0/Hydroxyindoleacetic Acid

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