Document Detail

Altered central serotoninergic neurotransmission: a potential mechanism for profound fatigue complicating chronic hepatitis C.
MedLine Citation:
PMID:  11461159     Owner:  NLM     Status:  MEDLINE    
Altered central neurotransmission contributes to behavioural complications of chronic liver disease, such as pruritus and hepatic encephalopathy. Another behavioural complication of chronic liver disease, including chronic hepatitis C, is profound fatigue. Evidence that altered serotoninergic neurotransmission contributes to fatigue of central origin, and relief of profound fatigue in a patient with chronic hepatitis C associated with long-term ondansetron therapy, support the hypothesis that altered central serotoninergic neurotransmission contributes to fatigue complicating chronic hepatitis C. Drugs that specifically modulate serotoninergic neurotransmission may be effective in ameliorating fatigue in patients with chronic hepatitis C.
E A Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  57     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-19     Completed Date:  2001-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  133-4     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Department of Gastrointestinal and Liver Diseases, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Fatigue / complications,  physiopathology*
Hepatitis C, Chronic / complications,  physiopathology*
Serotonin / physiology*
Synaptic Transmission / physiology*
Reg. No./Substance:

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