Document Detail

Altered central nervous system processing of noxious stimuli contributes to decreased nociceptive responding in individuals at risk for hypertension.
MedLine Citation:
PMID:  12098621     Owner:  NLM     Status:  MEDLINE    
Previous evidence indicates that individuals with hypertension and those at increased risk for the disorder exhibit decreased pain perception. To test the hypothesis that attenuation of nociceptive processing in individuals at genetic risk for hypertension is related to differential central modulation of nociceptive transmission, the present study examined descending modulation, alpha-motoneuron excitability, and temporal summation of nociceptive input in young adults with and without a parental history of hypertension. Nociceptive flexion (NFR) and non-nociceptive Hoffman reflexes were assessed at rest and during performance of a mental arithmetic task. Temporal summation was assessed by examining NFR threshold in response to a series of five electrical pulses delivered at 2 Hz. Compared to participants without a parental history of hypertension, offspring of individuals with hypertension exhibited significantly higher NFR thresholds, suggesting that risk for hypertension may be associated with enhanced activation of central pain inhibition pathways.
Christopher R France; Shannon A Froese; Jesse C Stewart
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pain     Volume:  98     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-05     Completed Date:  2002-09-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
Department of Psychology, Ohio University, 245 Porter Hall, Athens, OH 45701, USA.
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MeSH Terms
Central Nervous System / physiopathology*
Electric Stimulation
H-Reflex / physiology
Hypertension / etiology*
Nociceptors / physiopathology*
Pain / physiopathology*
Pain Threshold
Reflex / physiology
Risk Factors
Skin / physiopathology
Stress, Psychological / etiology,  physiopathology
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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