Document Detail


Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
MedLine Citation:
PMID:  20405543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have demonstrated intraventricular infusions of propionic acid (PPA) a dietary and enteric short-chain fatty acid can produce brain and behavioral changes similar to those observed in autism spectrum disorder (ASD). The effects of PPA were further evaluated to determine if there are any alterations in brain lipids associated with the ASD-like behavioral changes observed following intermittent intraventricular infusions of PPA, the related enteric metabolite butyric acid (BUT) or phosphate-buffered saline vehicle. Both PPA and BUT produced significant increases (p < 0.001) in locomotor activity (total distance travelled and stereotypy). PPA and to a lesser extent BUT infusions decreased the levels of total monounsaturates, total omega6 fatty acids, total phosphatidylethanolamine plasmalogens, the ratio of omega6 : omega3 and elevated the levels of total saturates in separated phospholipid species. In addition, total acylcarnitines, total longchain (C12-C24) acylcarnitines, total short-chain (C2 to C9) acylcarnitines, and the ratio of bound to free carnitine were increased following infusions with PPA and BUT. These results provide evidence of a relationship between changes in brain lipid profiles and the occurrence of ASD-like behaviors using the autism rodent model. We propose that altered brain fatty acid metabolism may contribute to ASD.
Authors:
Raymond H Thomas; Kelly A Foley; Jennifer R Mepham; Lisa J Tichenoff; Fred Possmayer; Derrick F MacFabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  113     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-04-30     Revised Date:  2010-07-06    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-29     Citation Subset:  IM    
Affiliation:
The Kilee Patchell-Evans Autism Research Group, Department of Psychology and Biology, University of Western Ontario, London, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Brain / drug effects*,  metabolism*
Carnitine / analogs & derivatives*,  metabolism
Child
Child Development Disorders, Pervasive
Chromatography, Thin Layer / methods
Disease Models, Animal
Gas Chromatography-Mass Spectrometry / methods
Humans
Injections, Intraventricular / methods
Male
Motor Activity / drug effects
Phospholipids / metabolism*
Propionic Acids / administration & dosage*
Rats
Rats, Long-Evans
Spectrometry, Mass, Electrospray Ionization / methods
Stereotyped Behavior / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Propionic Acids; 0/acylcarnitine; 541-15-1/Carnitine; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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