| Altered brain dynamics during voluntary movement in individuals with Down syndrome. | |
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MedLine Citation:
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PMID: 21464774 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Individuals with Down syndrome have well known cognitive and sensorimotor impairments, however, the underlying neural processes are poorly understood. The objective of this study was to investigate the underlying spatial localization and functional connectivity during voluntary movements of the right index finger. Adults with Down syndrome and healthy control adults participated in this study. Cortical responses were recorded with a 151-channel magnetoencephalographic system. In the Down syndrome group, we observed two distinct patterns of brain activation, an ipsilateral pattern and a contralateral pattern in the low-frequency band. The two distinct patterns of neural activation and the altered underlying network dynamics have not been reported previously, and may reflect differences in sensorimotor organization. |
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Authors:
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Naznin Virji-Babul; Alexander Moiseev; Nadya Moiseeva; Wenqi Sun; Urs Ribary; Ira Lott |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: Neuroreport Volume: - ISSN: 1473-558X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Physical Therapy, University of British Columbia, Vancouver bDown Syndrome Research Foundation, MEG Laboratory cSchool of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada dDepartment of Psychology eUniversity of California, Irvine, California, USA. |
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