| Altered amino acid homeostasis and the development of fatigue by breast cancer radiotherapy patients: A pilot study. | |
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MedLine Citation:
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PMID: 20950596 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To examine altered amino acid homeostasis as a predisposing factor of fatigue in female radiotherapy breast cancer patients. DESIGN AND METHODS: Participants underwent breast-conserving surgery and adjuvant breast irradiation and were free from significant fatigue pre-radiotherapy. The Functional Assessment of Cancer Therapy fatigue subscale was used to assess fatigue pre- and post-radiotherapy. Blood biochemistry factors and urinary and plasma amino acid levels were measured. RESULTS: One third of 27 patients developed fatigue and were designated as the fatigued cohort. It was possible to differentiate between fatigued subjects pre- and post-radiotherapy based upon their urinary amino acid profiles. Univariate analysis supported altered amino acid homeostasis within the fatigued cohort. Urinary levels of histidine and alanine were increased pre-radiotherapy whilst threonine, methionine, alanine, serine, asparagine and glutamine levels were higher after 5weeks of radiotherapy for the fatigued cohort. CONCLUSIONS: Fatigue was accompanied by altered amino acid homeostasis with increased amino acid excretion suggestive of a catabolic response. |
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Authors:
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R Hugh Dunstan; Diane L Sparkes; Margaret M Macdonald; Tim K Roberts; Christopher Wratten; Mahesh B Kumar; Surinder Baines; J W Denham; Sarah A Gallagher; Tony Rothkirch |
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Publication Detail:
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Type: Journal Article Date: 2010-10-13 |
Journal Detail:
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Title: Clinical biochemistry Volume: 44 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 208-15 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The Canadian Society of Clinical Chemists. All rights reserved. |
Affiliation:
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School of Environmental & Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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