| Altered amino acid excretion in children with autism. | |
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MedLine Citation:
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PMID: 18510798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autism is a complex and life-long behavioural disorder of unknown aetiology. Recent reports have indicated the involvement of digestive tract dysfunction and possible complications from inadequate nutrition. In this study, 34 autistic children (12 untreated and 22 receiving therapeutic treatments related to digestive function and nutritional uptake) and 29 control subjects (all 5-15 years of age) were investigated to determine whether there were any anomalies in the urinary excretion of amino acids, glucose, sucrose, arabinose and tartaric acid using GC/FID and GC/MS analysis techniques. Significantly lower relative urinary levels of essential amino acids were revealed for both the untreated (mean +/- SEM, 32.53 +/- 3.09%) and treated (31.98 +/- 2.87%) autistic children compared with the controls (37.87 +/- 1.50%). There were no significant differences in measured excretions of sugars or tartaric acid. It was concluded that the untreated autistic children had evidence of altered metabolic homeostasis. |
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Authors:
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Craig Evans; R Hugh Dunstan; Tony Rothkirch; Tim K Roberts; Karl L Reichelt; Robyn Cosford; Gary Deed; Libby B Ellis; Diane L Sparkes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutritional neuroscience Volume: 11 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-05-30 Completed Date: 2009-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 9-17 Citation Subset: IM |
Affiliation:
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School of Environmental and Life Sciences, University of Newcastle, Callaghan, New south Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amino Acids / urine* Amino Acids, Essential / urine Arabinose / urine Autistic Disorder / drug therapy, urine* Child Child, Preschool Female Glycosuria Homeostasis Humans Male Sex Characteristics Sucrose / urine Tartrates / urine |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Essential; 0/Tartrates; 147-81-9/Arabinose; 526-83-0/tartaric acid; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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