Document Detail


Altered airway responsiveness in adult sheep born prematurely: effects of allergen exposure.
MedLine Citation:
PMID:  16908448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine the effects of preterm birth per se on airway function in adult sheep. Preterm birth was induced at approximately 0.89 of term. At approximately 1 year of age the authors measured pulmonary resistance (RL) and airway responsiveness before and after house dust mite (HDM) challenge. Mature preterm sheep tended to have greater baseline RL than controls (P = .12): the smaller preterm sheep showed significantly greater RL than controls following bronchoconstrictor challenge. Preterm animals tended to have greater baseline total blood leukocyte count (P = .06). It was concluded that preterm sheep, especially with low postnatal growth, have greater airway responsiveness to bronchoconstrictor and higher baseline RL.
Authors:
Kenneth J Snibson; Robert J Bischof; Emmanuel Koumoundouros; Lachlan S McMurtrie; Megan Cock; Richard Harding
Related Documents :
16045948 - The shetland islands scrapie monitoring and control programme: analysis of the clinical...
25411758 - Committee opinion no. 614: management of pregnant women with presumptive exposure to li...
22004568 - Changes in the maternal hypothalamic-pituitary-adrenal axis during the early puerperium...
3314988 - Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-...
11854648 - Elevated amniotic fluid c-reactive protein at the time of genetic amniocentesis is a ma...
11831048 - Premarital sex, schoolgirl pregnancy, and school quality in rural kenya.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  32     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:    2006 Jun-Jul
Date Detail:
Created Date:  2006-08-15     Completed Date:  2006-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-28     Citation Subset:  IM    
Affiliation:
Centre for Animal Biotechnology, Department of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia. ksnibson@unimelb.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Airway Resistance / physiology*
Allergens / administration & dosage*
Animals
Asthma / immunology,  physiopathology,  veterinary*
Birth Weight
Body Weight
Bronchial Hyperreactivity / immunology,  physiopathology,  veterinary*
Bronchial Provocation Tests / veterinary
Bronchoalveolar Lavage Fluid / cytology
Bronchoconstrictor Agents / diagnostic use
Female
Leukocyte Count / veterinary
Male
Pregnancy
Premature Birth / physiopathology*
Pyroglyphidae / immunology
Sheep
Sheep Diseases / immunology,  physiopathology*
Chemical
Reg. No./Substance:
0/Allergens; 0/Bronchoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro...
Next Document:  Asbestos-induced activation of cell signaling pathways in human bronchial epithelial cells.