Document Detail

Altered airway responsiveness in adult sheep born prematurely: effects of allergen exposure.
MedLine Citation:
PMID:  16908448     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the effects of preterm birth per se on airway function in adult sheep. Preterm birth was induced at approximately 0.89 of term. At approximately 1 year of age the authors measured pulmonary resistance (RL) and airway responsiveness before and after house dust mite (HDM) challenge. Mature preterm sheep tended to have greater baseline RL than controls (P = .12): the smaller preterm sheep showed significantly greater RL than controls following bronchoconstrictor challenge. Preterm animals tended to have greater baseline total blood leukocyte count (P = .06). It was concluded that preterm sheep, especially with low postnatal growth, have greater airway responsiveness to bronchoconstrictor and higher baseline RL.
Kenneth J Snibson; Robert J Bischof; Emmanuel Koumoundouros; Lachlan S McMurtrie; Megan Cock; Richard Harding
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  32     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:    2006 Jun-Jul
Date Detail:
Created Date:  2006-08-15     Completed Date:  2006-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-28     Citation Subset:  IM    
Centre for Animal Biotechnology, Department of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Airway Resistance / physiology*
Allergens / administration & dosage*
Asthma / immunology,  physiopathology,  veterinary*
Birth Weight
Body Weight
Bronchial Hyperreactivity / immunology,  physiopathology,  veterinary*
Bronchial Provocation Tests / veterinary
Bronchoalveolar Lavage Fluid / cytology
Bronchoconstrictor Agents / diagnostic use
Leukocyte Count / veterinary
Premature Birth / physiopathology*
Pyroglyphidae / immunology
Sheep Diseases / immunology,  physiopathology*
Reg. No./Substance:
0/Allergens; 0/Bronchoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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