Document Detail

Altered age-related blood pressure pattern in type 1 diabetes.
MedLine Citation:
PMID:  15326070     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabetic patients differ from those of the nondiabetic METHODS AND RESULTS: We performed a cross-sectional, case-control study of 2988 consecutively selected diabetic subjects and 5486 randomly selected nondiabetic control subjects. Blood pressure was measured twice by mercury sphygmomanometry on a single occasion. Compared with controls, diabetic subjects had a higher systolic blood pressure in all age groups, whereas diastolic blood pressure was higher in those <40 years but lower in those >45 years of age. Consequently, diabetic subjects had a higher PP and a higher prevalence of isolated systolic hypertension. The early age-related rise in PP was more pronounced in subjects with diabetic nephropathy but was also evident in diabetic subjects with normal albumin excretion rate. In a multiple regression analysis, PP in diabetic patients was associated with age, male sex, duration of diabetes, and albuminuria. CONCLUSIONS: A higher systolic pressure and an earlier decrease in diastolic pressure result in a higher and more rapidly increasing PP in type 1 diabetic patients. Our findings indicate accelerated arterial aging, which may contribute to the higher cardiovascular morbidity and mortality in these patients.
Mats Rönnback; Johan Fagerudd; Carol Forsblom; Kim Pettersson-Fernholm; Antti Reunanen; Per-Henrik Groop;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-08-23
Journal Detail:
Title:  Circulation     Volume:  110     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-01     Completed Date:  2005-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1076-82     Citation Subset:  AIM; IM    
Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.
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MeSH Terms
Age of Onset
Aging / physiology*
Albuminuria / epidemiology,  etiology
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / complications,  physiopathology*
Diabetic Nephropathies / epidemiology
Diastole / physiology
Disease Susceptibility
Hypertension / drug therapy,  epidemiology*,  etiology
Middle Aged
Systole / physiology
Vascular Resistance / physiology
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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