| Altered Transcriptional Regulation of Cytokines, Growth Factors, and Apoptotic Proteins in the Endometrium of Infertile Women with Chronic Endometritis. | |
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MedLine Citation:
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PMID: 23351011 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PROBLEM: Chronic endometritis (CE) is a poorly investigated and probably underestimated pathology, which may cause abnormal uterine bleeding (AUB), pain, and reproductive failures. Due to undefined symptoms and the normal presence of leukocytes in the endometrial mucosa, diagnosis may be missed. Fluid hysteroscopy is a reliable technique for diagnosing this pathology. Few data exist on the biochemical and paracrine alterations that occur in the endometrium of women diagnosed with CE. The aim of the study was to find molecular modification in endometrium related to CE. METHOD OF STUDY: Sixteen women with hysteroscopic and histological diagnosis of CE and 10 healthy women as controls were enrolled. We compared the endometrial expression profile of 25 genes encoding proteins involved in the inflammatory response, proliferation, and apoptosis in endometrium during implantation window, using high-throughput real-time RT-PCR. RESULTS: In women with CE, the endometrial expression of some genes was significantly altered. In particular, IGFBP1, BCL2, and BAX were up-regulated, while IL11, CCL4, IGF1, and CASP8 were down-regulated. CONCLUSION: The altered gene endometrial expression may explain the impaired endometrial receptivity and the finding of endometrial hyperplastic lesions in women affected by CE. |
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Authors:
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Cinzia Di Pietro; Ettore Cicinelli; Maria R Guglielmino; Marco Ragusa; Marco Farina; Marco A Palumbo; Antonio Cianci |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: - ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 John Wiley & Sons A/S. |
Affiliation:
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Dipartimento G.F. Ingrassia, Biologia Generale, Biologia Cellulare, Genetica Molecolare G Sichel, Az. Policlinico, Università di Catania, Catania, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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