Document Detail

Altered T cell subsets and function in polytransfused beta-thalassemia patients: correlation with sex and age at first transfusion.
MedLine Citation:
PMID:  3873136     Owner:  NLM     Status:  MEDLINE    
Monoclonal antibodies (OKT series) have been used to investigate possible modifications of T lymphocytes and T lymphocyte subsets in 65 multiply transfused beta-thalassemia patients. No significant difference was observed in percentage and absolute number of OKT3-, OKT4-, and OKT8-positive cells when compared to controls. A subgroup of patients (10 patients, 15.3%), however, could be selected who showed a reversal of OKT4/OKT8 ratio. These patients did not differ from the others as to age, number of transfusions, frequency of splenectomy, ferritin levels, hepatitis B markers, chronic liver disease incidence, and numbers of B lymphocytes and natural killer cells. The features distinguishing this group from the remaining patients were: decreased mitogen responsiveness; early age when first transfused; high incidence of males (90%). Immunological investigation was done in 2 occasions, 1 year apart, but no significant modification was observed in these patients. These findings suggest that in beta-thalassemia patients transfusion therapy started very early in life may be responsible for persistent immunological modifications. The susceptibility to such modifications might be greater in males.
M De Martino; M E Rossi; A T Muccioli; C Vullo; A Vierucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vox sanguinis     Volume:  48     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  296-304     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antibodies, Monoclonal / analysis
Blood Transfusion*
Child, Preschool
Hepatitis, Chronic / complications
Lymphocyte Activation
Sex Factors
T-Lymphocytes / immunology*
Thalassemia / complications,  immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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