Document Detail

Altered states: psychedelics and anesthetics.
MedLine Citation:
PMID:  24061599     Owner:  NLM     Status:  MEDLINE    
The psychedelic experience has been reported since antiquity, but there is relatively little known about the underlying neural mechanisms. A recent neuroimaging study on psilocybin revealed a pattern of decreased cerebral blood flow and functional disconnections that is surprisingly similar to that caused by various anesthetics. In this article, the authors review historical examples of psychedelic experiences induced by general anesthetics and then contrast the mechanisms by which these two drug classes generate altered states of consciousness.
Eduardo E Icaza; George A Mashour
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  119     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-17     Completed Date:  2014-02-13     Revised Date:  2014-06-25    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1255-60     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthetics / history,  pharmacology*
Consciousness Disorders / chemically induced*,  psychology*
GABA Agents / pharmacology
Hallucinogens / history,  pharmacology*
History, 19th Century
History, Ancient
Psilocybine / pharmacology
Reg. No./Substance:
0/Anesthetics; 0/GABA Agents; 0/Hallucinogens; 2RV7212BP0/Psilocybine
Comment In:
Anesthesiology. 2014 Jun;120(6):1521-2   [PMID:  24845923 ]
Anesthesiology. 2014 Jun;120(6):1522-3   [PMID:  24845924 ]

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