Document Detail


Altered reactivity of tertiary mesenteric arteries following acute myocardial ischemia.
MedLine Citation:
PMID:  23172397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is unknown if cardiac ischemia has any deleterious effect on the contractile properties of nonischemic, peripheral vascular beds. Thus, the objective of the present study was to determine whether acute myocardial ischemia results in peripheral vascular dysfunction.
METHODS AND RESULTS: This study characterized force maintenance and the sensitivity to acetylcholine (ACh)-mediated smooth muscle (SM) relaxation of tertiary (3rd) mesenteric arteries from Sprague-Dawley rats following 30 min of myocardial ischemia. Both the phosphorylation of nonmuscle (NM) light chain (LC) and SM-LCs as well as the expression of myosin phosphatase targeting subunit 1 (MYPT1) were also determined. Our data demonstrate that acute myocardial ischemia resulted in vascular dysfunction of 3rd mesenteric vessels, characterized by decreases in force maintenance, ACh- and cGMP-mediated SM relaxation, the phosphorylation of NM-LCs and SM-LCs, and MYPT1 expression. Ischemia was also associated with an increase in protein polyubiquitination, suggesting that during ischemia MYPT1 is targeted for degradation or proteolysis.
CONCLUSION: Acute myocardial ischemia produces peripheral vascular dysfunction; the changes in LC phosphorylation and MYPT1 expression result in a decrease in both tone and the sensitivity to NO-mediated SM relaxation of the peripheral vasculature.
Authors:
Young Soo Han; Frank V Brozovich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-21
Journal Detail:
Title:  Journal of vascular research     Volume:  50     ISSN:  1423-0135     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-04-23     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  100-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Acute Disease
Animals
Biomechanical Phenomena
Cyclic GMP / analogs & derivatives,  pharmacology
Enzyme Induction / drug effects
Male
Membrane Potentials / drug effects
Mesenteric Arteries / physiopathology*
Muscle, Smooth, Vascular / drug effects,  physiopathology
Myocardial Infarction / physiopathology*
Myosin Light Chains / metabolism
Nitric Oxide / physiology
Phosphorylation / drug effects
Potassium Chloride / pharmacology
Protein Phosphatase 1 / metabolism
Protein Processing, Post-Translational / drug effects
Rats
Rats, Sprague-Dawley
Ubiquitination / drug effects
Vasodilation / drug effects
Grant Support
ID/Acronym/Agency:
R01 HL069894/HL/NHLBI NIH HHS; T32 HL007111/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Myosin Light Chains; 31356-94-2/8-bromocyclic GMP; 31C4KY9ESH/Nitric Oxide; 660YQ98I10/Potassium Chloride; EC 3.1.3.16/Ppp1r12a protein, rat; EC 3.1.3.16/Protein Phosphatase 1; H2D2X058MU/Cyclic GMP; N9YNS0M02X/Acetylcholine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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