| Altered RNA editing of serotonin 2C receptor in a rat model of depression. | |
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MedLine Citation:
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PMID: 16005997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Altered RNA editing of serotonin 2C receptor (HTR2C) has been suggested to be involved in the pathophysiology of major depression. Here we examined RNA editing status of HTR2C in the learned helplessness (LH) rats, one of well-established animal models of depression. LH rats showed the significantly increased RNA editing of site E, and tendency for increased RNA editing of other editing sites. Treatment with fluoxetine, a selective serotonin reuptake inhibitor, or imipramine, a tricyclic antidepressant, affected the RNA editing status of the LH rats. Although, these antidepressants differentially altered RNA editing status, they commonly reduced RNA editing efficiency of site E. We further revealed that altered RNA editing in the LH rats and by antidepressants was not explained by altered expression of RNA editing enzymes or their substrates (adenosine deaminases that act on RNA, HTR2C, and spliced form of HTR2C). These results suggest that alteration of RNA editing of HTR2C may play a role in the pathophysiology of depression and action of antidepressants. |
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Authors:
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Kazuya Iwamoto; Noriaki Nakatani; Miki Bundo; Takeo Yoshikawa; Tadafumi Kato |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience research Volume: 53 ISSN: 0168-0102 ISO Abbreviation: Neurosci. Res. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-01 Completed Date: 2005-10-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: IM |
Affiliation:
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Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako city, Saitama 351 0198, Japan. kaziwamoto@brain.riken.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Deaminase
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genetics,
metabolism Animals Antidepressive Agents / therapeutic use Cloning, Molecular Depression / drug therapy, genetics* Disease Models, Animal Gene Expression Regulation / drug effects, physiology Genetic Variation / physiology Helplessness, Learned* Male RNA Editing* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2C / genetics*, metabolism Reverse Transcriptase Polymerase Chain Reaction / methods Sequence Analysis / methods |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/RNA, Messenger; 0/Receptor, Serotonin, 5-HT2C; EC 3.5.4.-/dsRNA adenosine deaminase; EC 3.5.4.4/Adenosine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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