Document Detail


Altered proinflammatory cytokine production and enhanced resistance to Trypanosoma congolense infection in lymphotoxin beta-deficient mice.
MedLine Citation:
PMID:  19563258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BALB/c mice are highly susceptible to Trypanosoma congolense infection, whereas C57BL/6 mice are relatively resistant. Overproduction of interferon-gamma (IFN-gamma) and other proinflammatory cytokines contribute to death in susceptible mice. Here, we show that lymphotoxin beta-deficient (LTbeta(-/-)) mice are more resistant than wild-type (WT) mice to T. congolense infection, as shown by a lower parasitemia level and a longer survival duration. The enhanced resistance of LTbeta(-/-) mice was associated with undetectable or low serum levels of proinflammatory cytokines (i.e., tumor necrosis factor-alpha, interleukin [IL]-6, IL-12, and monocyte chemotactic protein-1). Although infected LTbeta(-/-) mice had high numbers of CD4(+)CD25(+)Foxp3(+) cells and high serum IL-10 levels, these cells were not the major producers of IL-10. Treatment of LTbeta(-/-) mice with anti-IL-10R monoclonal antibody abolished their enhanced resistance, whereas depletion of CD25(+) cells further enhanced resistance among infected WT and LTbeta(-/-) mice. These results suggest that LTbeta plays critical role in regulating the outcome of T. congolense infection in mice.
Authors:
Ifeoma Okwor; Helen Muleme; Ping Jia; Jude E Uzonna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  200     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-02     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / genetics,  metabolism*
Female
Gene Deletion
Gene Expression
Genetic Predisposition to Disease
Lymphotoxin-beta / genetics*,  metabolism
Mice
Mice, Inbred C57BL
Parasitemia
Signal Transduction
Specific Pathogen-Free Organisms
Trypanosoma congolense* / immunology
Trypanosomiasis, African / genetics,  immunology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Lymphotoxin-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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