Document Detail


Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.
MedLine Citation:
PMID:  20670470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a balanced diet until 90 days (MGL-R and MPW-R, respectively). After a glucose tolerance test (GTT), brains were processed for Fos immunoreactivity (Fos-IR). Both malnourished groups displayed hyperglycemia after GTT. MGL exhibited an increased number of Fos-IR neurons in the ventromedial hypothalamic nucleus (VMH), while MPW showed increased Fos-IR in the arcuate nucleus (ARC) and VMH and a decrease in the paraventricular nucleus (PVN), as compared with their controls. Nutritional rehabilitation normalized values of glucose after GTT in both groups, while low number of Fos-IR neurons remained in the ARC, PVN and VMH of MPW-R rats, indicating a deleterious, long-lasting effect after post-weaning malnutrition.
Authors:
María Del Carmen Miñana-Solis; Manuel Angeles-Castellanos; Ruud M Buijs; Carolina Escobar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  13     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-60     Citation Subset:  IM    
Affiliation:
Departamento de Anatomía, Facultad de Medicina, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / cytology
Blood Glucose / analysis
Cell Count
Diet, Protein-Restricted
Female
Glucose / administration & dosage*
Glucose Tolerance Test
Hypothalamus / cytology,  drug effects,  metabolism*
Immunohistochemistry
Injections, Intraperitoneal
Male
Malnutrition / diet therapy,  metabolism*,  rehabilitation
Maternal-Fetal Exchange
Neurons / chemistry,  cytology
Paraventricular Hypothalamic Nucleus / cytology
Pregnancy
Proto-Oncogene Proteins c-fos / analysis*
Rats
Rats, Wistar
Ventromedial Hypothalamic Nucleus / cytology
Weaning*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Proto-Oncogene Proteins c-fos; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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