Document Detail

Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.
MedLine Citation:
PMID:  20670470     Owner:  NLM     Status:  MEDLINE    
The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a balanced diet until 90 days (MGL-R and MPW-R, respectively). After a glucose tolerance test (GTT), brains were processed for Fos immunoreactivity (Fos-IR). Both malnourished groups displayed hyperglycemia after GTT. MGL exhibited an increased number of Fos-IR neurons in the ventromedial hypothalamic nucleus (VMH), while MPW showed increased Fos-IR in the arcuate nucleus (ARC) and VMH and a decrease in the paraventricular nucleus (PVN), as compared with their controls. Nutritional rehabilitation normalized values of glucose after GTT in both groups, while low number of Fos-IR neurons remained in the ARC, PVN and VMH of MPW-R rats, indicating a deleterious, long-lasting effect after post-weaning malnutrition.
María Del Carmen Miñana-Solis; Manuel Angeles-Castellanos; Ruud M Buijs; Carolina Escobar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  13     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-60     Citation Subset:  IM    
Departamento de Anatomía, Facultad de Medicina, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México.
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MeSH Terms
Arcuate Nucleus / cytology
Blood Glucose / analysis
Cell Count
Diet, Protein-Restricted
Glucose / administration & dosage*
Glucose Tolerance Test
Hypothalamus / cytology,  drug effects,  metabolism*
Injections, Intraperitoneal
Malnutrition / diet therapy,  metabolism*,  rehabilitation
Maternal-Fetal Exchange
Neurons / chemistry,  cytology
Paraventricular Hypothalamic Nucleus / cytology
Proto-Oncogene Proteins c-fos / analysis*
Rats, Wistar
Ventromedial Hypothalamic Nucleus / cytology
Reg. No./Substance:
0/Blood Glucose; 0/Proto-Oncogene Proteins c-fos; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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