Document Detail

Altered fecal microflora and increased fecal calprotectin in infants with colic.
MedLine Citation:
PMID:  19628216     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We explored whether gut inflammation, colonic fermentation, and/or an altered colonic flora could provide a pathophysiological mechanism for colic. STUDY DESIGN: The study population consisted of 36 term infants ranging in age from 14 to 81 days. We measured fecal calprotectin (a marker of neutrophil infiltration) by ELISA; stool microorganisms by denaturing gradient gel electrophoresis, cloning, and sequencing; and breath hydrogen levels using gas chromatography. RESULTS: During 24 hours, infants with colic (n = 19) cried and fussed for a mean of 314 +/- 36 (SEM) minutes, compared with control infants (n = 17, 103 +/- 17 minutes). Fecal calprotectin levels were 2-fold higher in infants with colic than in control infants (413 +/- 71 vs 197 +/- 46 microg/g, P = .042). Stools of infants with colic had fewer identifiable bands on denaturing gradient gel electrophoresis. Klebsiella species were detected in more colic patients than in control patients (8 vs 1, P = .02), whereas Enterobacter/Pantoea species were detected only in the control patients. These differences could not be attributed to differences in formula versus breast milk feeding, consumption of elemental formula, or exposure to antibiotics. CONCLUSIONS: Infants with colic, a condition previously believed to be nonorganic in nature, have evidence of intestinal neutrophilic infiltration and a less diverse fecal microflora.
J Marc Rhoads; Nicole Y Fatheree; Johana Norori; Yuying Liu; Joseph F Lucke; Jon E Tyson; Michael J Ferris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-22
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-828.e1     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Texas Health Sciences Center at Houston-School of Medicine, Houston, TX 77030, USA.
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MeSH Terms
Breath Tests
Case-Control Studies
Colic / metabolism*,  microbiology*,  pathology
Feces / chemistry*,  microbiology*
Gastroenteritis / complications,  metabolism,  microbiology
Hydrogen / metabolism
Infant, Newborn
Leukocyte L1 Antigen Complex / analysis,  metabolism*
Neutrophil Infiltration / physiology
Reg. No./Substance:
0/Leukocyte L1 Antigen Complex; 1333-74-0/Hydrogen
Comment In:
J Pediatr. 2009 Dec;155(6):772-3   [PMID:  19914427 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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