| Altered early left ventricular diastolic wall velocities in pulmonary hypertension: a tissue Doppler study. | |
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MedLine Citation:
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PMID: 19765074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is known to occur in severe chronic pulmonary hypertension (PH); however, the mechanism(s) remains unclear. METHODS: Tissue Doppler imaging (TDI) was used to track early (E) diastolic signals of basal and mid portions of the interventricular septum (IS) and LV free wall (LVFw) in 20 patients (60 +/- 8 years) with documented LVDD without PH and in 30 patients (60 +/- 11 years) with known chronic PH. All subjects were in normal sinus rhythm and had normal LV ejection fraction. RESULTS: PH patients had lower early (E) wave velocities in basal IS (-4.2 +/- 1.9 vs. -5.9 +/- 1.2 cm/sec; P < 0.001), distal IS (-2.6 +/- 2.6 vs. -4.2 +/- 1.1 cm/sec; P < 0.01), and basal LVFw (-5.2 +/- 1.7 vs. -6.5 +/- 1.2 cm/sec; P < 0.01) than patients with LVDD and no PH. Finally, worsening PH distorts the entire IS diastolic tracing resulting in asynchronous diastolic signals. CONCLUSIONS: The presence of PH not only decreases IS early (E) wave diastolic velocity generation but also distorts the entire pattern of IS diastolic relaxation when compared to patients with typical LVDD and no PH. Further studies are now needed to assess the full effect of PH on LV diastole and how this influences clinical outcomes. |
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Authors:
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Angel L??pez-Candales; Raveen Bazaz; Kathy Edelman; Beth Gulyasy |
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Publication Detail:
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Type: Journal Article Date: 2009-09-18 |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 26 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 1159-66 Citation Subset: IM |
Affiliation:
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Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, USA. lopezcandalesa@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Elasticity Imaging Techniques* Female Humans Hypertension, Pulmonary / complications*, ultrasonography* Male Middle Aged Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / etiology*, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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