| Altered cell motility and attachment with titanium surface modifications. | |
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MedLine Citation:
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PMID: 21486180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to periodontal tissues. METHODS: Three clinically relevant surfaces were tested: 1) machined titanium; 2) a titanium surface roughened through acid etching (dual thermal-etched titanium [DTET]); and 3) a titanium surface roughened with nanometer-scale calcium phosphate deposition (nanoscale calcium phosphate-impregnated titanium [NCPIT]). Cell attachment and migration were examined for four cell types: rat osteosarcoma cells, human osteoblasts, and gingival and periodontal ligament (PDL) fibroblasts. RESULTS: All four cell types attached to each of the three titanium surfaces equally by 2 hours, and the PDL and gingival fibroblasts generally displayed less attachment than the osteosarcoma cells and osteoblasts. The cells displayed differential motility and long-term attachment to each of the titanium surfaces. Osteosarcoma cells displayed preferential motility on NCPIT, whereas PDL fibroblasts were more motile on machined titanium, and gingival fibroblasts moved more rapidly on both DTET and NCPIT. Osteoblasts displayed little motility on any of the titanium surfaces and lost viability on NCPIT after 24 hours. Gingival fibroblasts lost attachment to machined titanium. CONCLUSIONS: Periodontal cells displayed differential motility and long-term attachment to titanium surfaces. Selective modification of titanium surface properties in various regions of an implant may be useful in guiding specific cell populations to specific locations where they might best aid in osseointegration and soft tissue remodeling. |
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Authors:
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Archontia Palaiologou; Diana Stoute; Yuwei Fan; Thomas E Lallier |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-12 |
Journal Detail:
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Title: Journal of periodontology Volume: 83 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-03 Completed Date: 2012-05-29 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 90-100 Citation Subset: D; IM |
Affiliation:
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Department of Periodontics, Louisiana State University Health Science Center, School of Dentistry, New Orleans, LA 70119, USA. apalai@lsuhsc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Calcium Phosphates* Cell Adhesion* Cell Line, Tumor Cell Movement* Cell Survival Cells, Cultured Dental Etching Dental Implants* Fibroblasts / cytology Gingiva / cytology Humans Nanostructures Osteoblasts / cytology*, physiology Periodontal Ligament / cytology Rats Surface Properties Titanium* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Phosphates; 0/Dental Implants; 7440-32-6/Titanium; 97Z1WI3NDX/calcium phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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