Document Detail


Altered cell motility and attachment with titanium surface modifications.
MedLine Citation:
PMID:  21486180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to periodontal tissues.
METHODS: Three clinically relevant surfaces were tested: 1) machined titanium; 2) a titanium surface roughened through acid etching (dual thermal-etched titanium [DTET]); and 3) a titanium surface roughened with nanometer-scale calcium phosphate deposition (nanoscale calcium phosphate-impregnated titanium [NCPIT]). Cell attachment and migration were examined for four cell types: rat osteosarcoma cells, human osteoblasts, and gingival and periodontal ligament (PDL) fibroblasts.
RESULTS: All four cell types attached to each of the three titanium surfaces equally by 2 hours, and the PDL and gingival fibroblasts generally displayed less attachment than the osteosarcoma cells and osteoblasts. The cells displayed differential motility and long-term attachment to each of the titanium surfaces. Osteosarcoma cells displayed preferential motility on NCPIT, whereas PDL fibroblasts were more motile on machined titanium, and gingival fibroblasts moved more rapidly on both DTET and NCPIT. Osteoblasts displayed little motility on any of the titanium surfaces and lost viability on NCPIT after 24 hours. Gingival fibroblasts lost attachment to machined titanium.
CONCLUSIONS: Periodontal cells displayed differential motility and long-term attachment to titanium surfaces. Selective modification of titanium surface properties in various regions of an implant may be useful in guiding specific cell populations to specific locations where they might best aid in osseointegration and soft tissue remodeling.
Authors:
Archontia Palaiologou; Diana Stoute; Yuwei Fan; Thomas E Lallier
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-12
Journal Detail:
Title:  Journal of periodontology     Volume:  83     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-03     Completed Date:  2012-05-29     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-100     Citation Subset:  D; IM    
Affiliation:
Department of Periodontics, Louisiana State University Health Science Center, School of Dentistry, New Orleans, LA 70119, USA. apalai@lsuhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Calcium Phosphates*
Cell Adhesion*
Cell Line, Tumor
Cell Movement*
Cell Survival
Cells, Cultured
Dental Etching
Dental Implants*
Fibroblasts / cytology
Gingiva / cytology
Humans
Nanostructures
Osteoblasts / cytology*,  physiology
Periodontal Ligament / cytology
Rats
Surface Properties
Titanium*
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 0/Dental Implants; 7440-32-6/Titanium; 97Z1WI3NDX/calcium phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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