| Altered Brain Metabolism After Whole Body Irradiation in Mice: A Preliminary in vivo (1)H MRS Study. | |
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MedLine Citation:
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PMID: 23020784 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Purpose: In the classical description of acute radiation syndrome, the role of central nervous system (CNS) is underestimated. It is now well recognised that ionising radiation induced oxidative stress may bring about functional changes in brain. In this study, we prospectively evaluated metabolic changes in brain after whole body irradiation in mice using in vivo proton (1H) nuclear magnetic resonance spectroscopy (MRS). Material and Methods: Young adult mice were exposed to whole body irradiation of 8 Gy and controls were sham irradiated. In vivo (1)H MRS from cortex-hippocampus and hypothalamic-thalamic region of brain at different time points i.e as early as 6 hours, day 1, 2, 3, 5 and 10 post irradiation was carried out at 7 Tesla animal magnetic resonance imaging system. Brain metabolites were measured and quantitative analysis of detectable metabolites was performed by linear combination of model (LCModel). Results: Significant reduction in myoinositol (p=0.03) and taurine (p=0.02) ratios were observed in cortex-hippocampus region as early as day 2 post irradiation compared to controls. These metabolic alterations remained sustained over day 10 post irradiation. Conclusions: The results of this preliminary study suggest that the alteration/reduction in the mI and Tau concentration may be associated with physiological perturbations in astrocytes or radiation induced neuro-inflammatory response triggered in microglial cell. |
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Authors:
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Poonam Rana; Ahmad Raza Khan; Shipli Modi; B S Hemanth Kumar; Salim Javed; Rajendra Prasad Tripathi; Subash Khushu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-1 |
Journal Detail:
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Title: International journal of radiation biology Volume: - ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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