Document Detail


Altered brain metabolism after whole body irradiation in mice: a preliminary in vivo 1H MRS study.
MedLine Citation:
PMID:  23020784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MATERIAL AND METHODS: Young adult mice were exposed to whole body irradiation of 8 Gy and controls were sham irradiated. In vivo (1)H MRS from cortex-hippocampus and hypothalamic-thalamic region of brain at different time points, i.e., as early as 6 hours, day 1, 2, 3, 5 and 10 post irradiation was carried out at 7 Tesla animal magnetic resonance imaging system. Brain metabolites were measured and quantitative analysis of detectable metabolites was performed by linear combination of model (LCModel).
RESULTS: Significant reduction in myoinositol (p = 0.03) and taurine (p = 0.02) ratios were observed in cortex-hippocampus region as early as day 2 post irradiation compared to controls. These metabolic alterations remained sustained over day 10 post irradiation.
CONCLUSIONS: The results of this preliminary study suggest that the alteration/reduction in the mI and Tau concentration may be associated with physiological perturbations in astrocytes or radiation induced neuro-inflammatory response triggered in microglial cell.
Authors:
Poonam Rana; Ahmad Raza Khan; Shilpi Modi; B S Hemanth Kumar; Salim Javed; Rajendra Prasad Tripathi; Subash Khushu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  International journal of radiation biology     Volume:  89     ISSN:  1362-3095     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-04-24     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  212-8     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid / analogs & derivatives,  metabolism
Brain / metabolism*,  radiation effects*
Cerebral Cortex / metabolism,  radiation effects
Choline / metabolism
Creatine / metabolism
Glutamic Acid / metabolism
Glutamine / metabolism
Hippocampus / metabolism,  radiation effects
Hypothalamus / metabolism,  radiation effects
Inositol / metabolism
Magnetic Resonance Spectroscopy
Male
Mice
Models, Neurological
Oxidative Stress / radiation effects
Phosphocreatine / metabolism
Taurine / metabolism
Thalamus / metabolism,  radiation effects
Time Factors
Tissue Distribution
Chemical
Reg. No./Substance:
020IUV4N33/Phosphocreatine; 0RH81L854J/Glutamine; 1EQV5MLY3D/Taurine; 30KYC7MIAI/Aspartic Acid; 3KX376GY7L/Glutamic Acid; 4L6452S749/Inositol; 997-55-7/N-acetylaspartate; MU72812GK0/Creatine; N91BDP6H0X/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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