Document Detail

Altered Brain Metabolism After Whole Body Irradiation in Mice: A Preliminary in vivo (1)H MRS Study.
MedLine Citation:
PMID:  23020784     Owner:  NLM     Status:  Publisher    
Abstract Purpose: In the classical description of acute radiation syndrome, the role of central nervous system (CNS) is underestimated. It is now well recognised that ionising radiation induced oxidative stress may bring about functional changes in brain. In this study, we prospectively evaluated metabolic changes in brain after whole body irradiation in mice using in vivo proton (1H) nuclear magnetic resonance spectroscopy (MRS). Material and Methods: Young adult mice were exposed to whole body irradiation of 8 Gy and controls were sham irradiated. In vivo (1)H MRS from cortex-hippocampus and hypothalamic-thalamic region of brain at different time points i.e as early as 6 hours, day 1, 2, 3, 5 and 10 post irradiation was carried out at 7 Tesla animal magnetic resonance imaging system. Brain metabolites were measured and quantitative analysis of detectable metabolites was performed by linear combination of model (LCModel). Results: Significant reduction in myoinositol (p=0.03) and taurine (p=0.02) ratios were observed in cortex-hippocampus region as early as day 2 post irradiation compared to controls. These metabolic alterations remained sustained over day 10 post irradiation. Conclusions: The results of this preliminary study suggest that the alteration/reduction in the mI and Tau concentration may be associated with physiological perturbations in astrocytes or radiation induced neuro-inflammatory response triggered in microglial cell.
Poonam Rana; Ahmad Raza Khan; Shipli Modi; B S Hemanth Kumar; Salim Javed; Rajendra Prasad Tripathi; Subash Khushu
Related Documents :
19886134 - How often does computed tomography change the management of acute appendicitis?
22961264 - Metabolic changes in the spinal cord after brachial plexus root re-implantation.
23713094 - Teaching neuroimages: vein of galen aneurysm mimicking pineal mass in a young adult.
22692884 - The incidence of invasion and metastasis of nasopharyngeal carcinoma at different anato...
22936634 - Multimodality 3d-roadmap for cardiovascular interventions in congenital heart disease -...
10813284 - Craniocervical junction involvement in rheumatoid arthritis: a clinical and radiologica...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  International journal of radiation biology     Volume:  -     ISSN:  1362-3095     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinicopathological analysis of mediastinal large B-cell lymphoma and classical Hodgkin lymphoma of ...
Next Document:  Changes in the expression of aromatase, estrogen receptor alpha and beta in mandibular condylar cart...