| Alterations to nuclear architecture and genome behavior in senescent cells. | |
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MedLine Citation:
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PMID: 17460187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions. Many of the studies researching the importance of genome organization and nuclear structure are performed in young, proliferating, and often transformed cells. These studies do not reveal anything about the nucleus or genome in nonproliferating cells, which may be relevant for the regulation of both proliferation and replicative senescence. Here, we provide an overview of what is known about the genome and nuclear structure in senescent cells. We review the evidence that nuclear structures, such as the nuclear lamina, nucleoli, the nuclear matrix, nuclear bodies (such as promyelocytic leukemia bodies), and nuclear morphology all become altered within growth-arrested or senescent cells. Specific alterations to the genome in senescent cells, as compared to young proliferating cells, are described, including aneuploidy, chromatin modifications, chromosome positioning, relocation of heterochromatin, and changes to telomeres. |
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Authors:
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Ishita S Mehta; Martin Figgitt; Craig S Clements; Ian R Kill; Joanna M Bridger |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1100 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 250-63 Citation Subset: IM |
Affiliation:
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Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, West London, UB8 3PH, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cell Aging* Cell Nucleolus / metabolism Cell Nucleus / metabolism* Cell Proliferation Chromosomes / metabolism, ultrastructure Disease Models, Animal Genome Humans Leukemia, Promyelocytic, Acute / metabolism Mice Models, Biological Nuclear Matrix / metabolism Telomere / ultrastructure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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