Document Detail


Alterations of the tear film and ocular surface health in chronic smokers.
MedLine Citation:
PMID:  18425058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effects of chronic smoking on ocular surface and tear functions. METHODS: Fifteen right eyes of 15 healthy chronic smokers (9 men, 6 women; age range: 36-47 years) who smoked 20 cigarettes per day for 20 years and 20 eyes of 20 control non-smokers (12 men, 8 women; age range: 38-43 years) were included in this prospective study. All subjects underwent measurements of breath and haemoglobin CO concentration, tear lipid layer interferometry, evaporimetry, tear film break-up time (TBUT), Schirmer's I test, corneal fluorescein staining, conjunctival impression, and brush cytology. RESULTS: The mean Hb CO level was significantly higher in smokers compared to non-smokers. TBUT was also significantly shorter in smokers. Tear lipid layer showed significant slowing in spread over the tear film with a concomitant significant increase in tear evaporation rate. Conjunctival impression cytology revealed significant loss of goblet cells and squamous metaplasia in smokers. Brush cytology showed significant conjunctival neutrophil infiltration in smoker subjects. CONCLUSION: Chronic smoking induced distinctive quantitative and qualitative disturbances on the ocular surface health.
Authors:
Y Matsumoto; M Dogru; E Goto; Y Sasaki; H Inoue; I Saito; J Shimazaki; K Tsubota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  Eye (London, England)     Volume:  22     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-12-29     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  961-8     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Breath Tests / methods
Capnography
Carbon Dioxide / physiology
Case-Control Studies
Conjunctiva / pathology
Enzyme-Linked Immunosorbent Assay / methods
Eye Diseases / etiology
Female
Glycine / analogs & derivatives,  analysis
Humans
Lipid Metabolism
Male
Middle Aged
Neutrophils / pathology
Smoking / adverse effects,  pathology,  physiopathology*
Specimen Handling / methods
Tears / chemistry,  physiology*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 24003-67-6/N-caproylglycine; 56-40-6/Glycine
Comments/Corrections
Erratum In:
Eye. 2008 Jul;22(7):983

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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