Document Detail

Alterations of the tear film and ocular surface health in chronic smokers.
MedLine Citation:
PMID:  18425058     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects of chronic smoking on ocular surface and tear functions. METHODS: Fifteen right eyes of 15 healthy chronic smokers (9 men, 6 women; age range: 36-47 years) who smoked 20 cigarettes per day for 20 years and 20 eyes of 20 control non-smokers (12 men, 8 women; age range: 38-43 years) were included in this prospective study. All subjects underwent measurements of breath and haemoglobin CO concentration, tear lipid layer interferometry, evaporimetry, tear film break-up time (TBUT), Schirmer's I test, corneal fluorescein staining, conjunctival impression, and brush cytology. RESULTS: The mean Hb CO level was significantly higher in smokers compared to non-smokers. TBUT was also significantly shorter in smokers. Tear lipid layer showed significant slowing in spread over the tear film with a concomitant significant increase in tear evaporation rate. Conjunctival impression cytology revealed significant loss of goblet cells and squamous metaplasia in smokers. Brush cytology showed significant conjunctival neutrophil infiltration in smoker subjects. CONCLUSION: Chronic smoking induced distinctive quantitative and qualitative disturbances on the ocular surface health.
Y Matsumoto; M Dogru; E Goto; Y Sasaki; H Inoue; I Saito; J Shimazaki; K Tsubota
Related Documents :
15491638 - Studies on the hprt mutant frequency in t lymphocytes from healthy indian male populati...
17869028 - An analysis of racial and sex differences for smoking among adolescents in a juvenile c...
19892378 - Secular trends in adult male smoking from 1992 to 2006 in south korea: age-specific cha...
48848 - Cigarette smoking and respiratory ill-health in the british army.
16186528 - Dementia incidence may increase more slowly after age 90: results from the bronx aging ...
17214148 - Prevalence of schistosoma mansoni and intestinal parasites with evaluation of hepatic s...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  Eye (London, England)     Volume:  22     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-12-29     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  961-8     Citation Subset:  IM    
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Breath Tests / methods
Carbon Dioxide / physiology
Case-Control Studies
Conjunctiva / pathology
Enzyme-Linked Immunosorbent Assay / methods
Eye Diseases / etiology
Glycine / analogs & derivatives,  analysis
Lipid Metabolism
Middle Aged
Neutrophils / pathology
Smoking / adverse effects,  pathology,  physiopathology*
Specimen Handling / methods
Tears / chemistry,  physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 24003-67-6/N-caproylglycine; 56-40-6/Glycine
Erratum In:
Eye. 2008 Jul;22(7):983

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Imaging neuroendocrine tumours with radionuclide techniques.
Next Document:  Ocular manifestations in oculodentodigital dysplasia resulting from a heterozygous missense mutation...