Document Detail


Alterations of taste perception in Crohn's disease and their dependency on disease activity and nutritional behavior.
MedLine Citation:
PMID:  19247206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The pathogenesis of Crohn's disease (CD) is unknown. Besides immunoregulatory, genetic and environmental aspects, a nutritional impact is also encountered. Whether taste perception exerts any influence on an increased consumption of carbohydrates is unknown. OBJECTIVE: To evaluate nutritional habits and taste perception in CD patients, either in active or inactive disease stages. DESIGN: A prospective study was performed with 31 active and 27 inactive CD patients, and 30 age and sex-matched healthy subjects. Nutritional behavior was determined using an extensive optical nutrition questionnaire and taste perception was assessed by a 3-drop method with exceeding dilution tests. RESULTS: Active and inactive CD patients exhibited a significant increased taste threshold for the detection of all solutions (bitter: P=0.0012; salty: P=0.0198; sour: P=0.0021; and sweet: P=0.0208). For recognition, the determination of bitter solution (P=0.0014) was significantly reduced in CD patients compared with healthy subjects. No impact of clinical or objective parameters of inflammation on taste perception could be established. The consumption of refined sugar in CD patients was higher than in healthy subjects, though not significant. CONCLUSIONS: An increased taste threshold for the detection of all 4 taste qualities in active and inactive CD patients suggests a systemic pathogenesis, such as an inflammation of the oral cavity, as a manifestation of CD. In this study, changes in taste threshold were not associated with altered sugar consumption.
Authors:
Yurdagül Zopf; Christina Rabe; Sylvia Kollmann; Eckhart Georg Hahn; Norbert Thürauf; Dieter Schwab
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  43     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Affiliation:
Department of Medicine 1, Friedrich-Alexander-University Erlangen Nuremberg, Ulmenweg 18, Erlangen91054, Germany. yurdaguel.zopf@uk-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Crohn Disease / complications*,  physiopathology
Dietary Carbohydrates / administration & dosage
Dietary Sucrose / administration & dosage
Feeding Behavior
Female
Food Preferences*
Humans
Male
Middle Aged
Prospective Studies
Questionnaires
Taste Perception*
Taste Threshold
Young Adult
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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