Document Detail

Alterations of skin-associated lymphoid tissue in the carcinogenesis of arsenical skin cancer.
MedLine Citation:
PMID:  1385879     Owner:  NLM     Status:  MEDLINE    
We investigated the skin-associated lymphoid tissue in arsenical skin cancers, including 14 Bowen's disease, 6 basal cell carcinoma and 6 squamous cell carcinoma patients from an endemic area by immunohistochemical and morphometric methods. There was a progressive decrease of Langerhans cells in the order of normal skin, normal appearing edge and arsenical cancers. A disruption of the uniform Langerhans cell dendrites was also noticed. The Langerhans cell density in arsenical tumors did not correlate with the peritumoral infiltrates. The prominent infiltrated cells in the peritumoral area had T cell markers. The number of peritumoral T lymphocytes in squamous cell carcinoma was significantly less than that of Bowen's disease and basal cell carcinoma. Peritumoral mononuclear infiltrates in Bowen's disease and squamous cell carcinoma showed a higher helper/suppressor T cell ratio than that in basal cell carcinoma. This may be accounted for by a selective increased recruitment of helper T cells to the tumor infiltrates in Bowen's disease and squamous cell carcinoma.
H S Yu; G S Chen; H M Sheu; J S Kao; K L Chang; C L Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Science Council, Republic of China. Part B, Life sciences     Volume:  16     ISSN:  0255-6596     ISO Abbreviation:  Proc. Natl. Sci. Counc. Repub. China B     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-08-14     Completed Date:  1992-08-14     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  8502426     Medline TA:  Proc Natl Sci Counc Repub China B     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Department of Dermatology, Kaohsiung Medical College, Republic of China.
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MeSH Terms
Arsenic Poisoning*
Bowen's Disease / chemically induced,  pathology
Carcinoma, Basal Cell / chemically induced,  pathology
Carcinoma, Squamous Cell / chemically induced,  pathology
Dendrites / pathology
Langerhans Cells / pathology
Lymphoid Tissue / immunology,  pathology*
Skin / pathology*
Skin Neoplasms / chemically induced*,  pathology
T-Lymphocytes / pathology
T-Lymphocytes, Helper-Inducer / pathology
T-Lymphocytes, Regulatory / pathology

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