| Alterations of regular and mature monocytes are distinct, and dependent of intensity and duration of exercise. | |
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MedLine Citation:
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PMID: 7805676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circulating monocytes comprise functionally distinct regular (CD14bright+) and mature (CD14low+) cells. Cell surface receptors were determined by three colour flow cytometry in 8 healthy control subjects. Compared to regular monocytes, mature monocytes had lower levels of the high affinity Fc gamma receptor 1 (CD64), complement receptor 3 (CD11b), CD45RO and higher levels for HLA-DR, LFA-1 (CD11a/CD18), interleukin-2 receptor (CD25), CD45RA and the Fc gamma receptor 3 (CD16). Both regular and mature monocytes were measured before and up to three hours after four different types of exercise (Ex) in endurance trained athletes (n = 9-16). Immediately after anaerobic exercise of 1 min with a maximal lactate concentration (la max) of 12.3 (SD 1.4) mmol.1-1 and exhaustive exercise of 24 (SD 8) min with a maximal lactate concentration (lamax) of 7.4 (SD 2.6) mmol..-1 mature monocytes increased more than regular monocytes. Exhaustive endurance exercise of 87 (SD 21) min [lamax 3.7 (SD 1.0)] led to a similar increase of regular and mature monocytes. 15-33 min after a 100km run regular monocytes increased significantly, whereas mature monocytes decreased. Up to three hours after the end of all exercises mature monocytes fell below pre-exercise values. In conclusion, duration and intensity of exercise alter distinct maturation stages of monocytes differently. It is probable that the avidity of adhesion molecules like LFA-1 to their endothelial ligands is increased to enable the firm attachment to the endothelium. |
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Authors:
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H Gabriel; A Urhausen; L Brechtel; H J Müller; W Kindermann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 69 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1994 |
Date Detail:
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Created Date: 1995-01-31 Completed Date: 1995-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 179-81 Citation Subset: IM |
Affiliation:
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Institute of Sports and Performance Medicine, University of Saarland, Saarbrücken, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Cell Count Cell Adhesion Molecules Exercise / physiology* Female Flow Cytometry Humans Lactates / blood Lactic Acid Male Monocytes / physiology* Phenotype Receptors, Cell Surface / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Lactates; 0/Receptors, Cell Surface; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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