Document Detail


Alterations of regular and mature monocytes are distinct, and dependent of intensity and duration of exercise.
MedLine Citation:
PMID:  7805676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating monocytes comprise functionally distinct regular (CD14bright+) and mature (CD14low+) cells. Cell surface receptors were determined by three colour flow cytometry in 8 healthy control subjects. Compared to regular monocytes, mature monocytes had lower levels of the high affinity Fc gamma receptor 1 (CD64), complement receptor 3 (CD11b), CD45RO and higher levels for HLA-DR, LFA-1 (CD11a/CD18), interleukin-2 receptor (CD25), CD45RA and the Fc gamma receptor 3 (CD16). Both regular and mature monocytes were measured before and up to three hours after four different types of exercise (Ex) in endurance trained athletes (n = 9-16). Immediately after anaerobic exercise of 1 min with a maximal lactate concentration (la max) of 12.3 (SD 1.4) mmol.1-1 and exhaustive exercise of 24 (SD 8) min with a maximal lactate concentration (lamax) of 7.4 (SD 2.6) mmol..-1 mature monocytes increased more than regular monocytes. Exhaustive endurance exercise of 87 (SD 21) min [lamax 3.7 (SD 1.0)] led to a similar increase of regular and mature monocytes. 15-33 min after a 100km run regular monocytes increased significantly, whereas mature monocytes decreased. Up to three hours after the end of all exercises mature monocytes fell below pre-exercise values. In conclusion, duration and intensity of exercise alter distinct maturation stages of monocytes differently. It is probable that the avidity of adhesion molecules like LFA-1 to their endothelial ligands is increased to enable the firm attachment to the endothelium.
Authors:
H Gabriel; A Urhausen; L Brechtel; H J Müller; W Kindermann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  69     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-31     Completed Date:  1995-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  IM    
Affiliation:
Institute of Sports and Performance Medicine, University of Saarland, Saarbrücken, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Cell Count
Cell Adhesion Molecules
Exercise / physiology*
Female
Flow Cytometry
Humans
Lactates / blood
Lactic Acid
Male
Monocytes / physiology*
Phenotype
Receptors, Cell Surface / physiology
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Lactates; 0/Receptors, Cell Surface; 50-21-5/Lactic Acid

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