| Alterations of rat liver subsequent to heat overload. | |
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MedLine Citation:
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PMID: 580363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since pathological changes in the liver are among the consistent findings in humans subsequent to heatstroke, specimens were taken from the liver in rats during a study to assess the rat as a model for human heatstroke. Tissues from four groups of rats were processed for light and electron microscopy. The groups consisted of control rats, rats run to exhaustion at 5 C, rats exhausted at 26 C, and rats restrained at 41.5 C until their rectal temperatures reached 42.3 C. Exhaustive exercise at 5 C produced neither fatalities nor pathological changes in the livers. Exhaustive exercise at 26 C and restraint at 41.5 C were fatal for most rats. Histological and/or ultrastructural changes, which included centrilobular necrosis, vacuolization and diminution of hepatocellular microvilli, and loss of sinusoidal endothelium, were observed in livers from rats that were run to exhaustion at 26 C and from those rats restrained at 41.5 C. This work supports the validity of the rat model, since human heatstroke results in similar hepatic changes. |
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Authors:
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W D Bowers; R W Hubbard; I Leav; R Daum; M Conlon; M P Hamlet; M Mager; P Brandt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 102 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-05-08 Completed Date: 1978-05-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 154-7 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heat Exhaustion / complications, pathology* Liver / pathology* Liver Diseases / etiology, pathology Male Necrosis Rats |
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