Document Detail

Alterations of rat cardiac adenylate cyclase activity with age.
MedLine Citation:
PMID:  3758167     Owner:  NLM     Status:  MEDLINE    
Basal, 5'-guanylimidodiphosphate, GTP-, NaF-, forskolin-, D,L-isoproterenol-, glucagon- and secretin-stimulated adenylate cyclase activities were investigated in cardiac membranes from young adult (6 month old), old (20 month old) and senescent (24 month old) Sprague Dawley rats. The only significant difference between old and young adult rats was a 43% decrease of the glucagon-stimulated enzyme activity. In senescent rats compared to young adult rats, we observed a 23% decrease in forskolin-stimulated enzyme activity, a more severe (-73%) decrease in glucagon-stimulated adenylate cyclase activity and a decrease (-38%) of the response to secretin. The response to the beta-adrenoreceptor agonist D,L-isoproterenol was unaffected. These results suggest an alteration with age in the vicinity of the catalytic unit of adenylate cyclase and a selective decrease of functional glucagon and secretin receptors.
P Robberecht; M Gillard; M Waelbroeck; J C Camus; P De Neef; J Christophe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  126     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-11-03     Completed Date:  1986-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
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MeSH Terms
Adenylate Cyclase / metabolism*
Forskolin / pharmacology
Glucagon / pharmacology
Guanylyl Imidodiphosphate / pharmacology
Isoproterenol / pharmacology
Myocardium / enzymology*
Rats, Inbred Strains
Secretin / pharmacology
Sodium Fluoride / pharmacology
Reg. No./Substance:
1393-25-5/Secretin; 34273-04-6/Guanylyl Imidodiphosphate; 66428-89-5/Forskolin; 7681-49-4/Sodium Fluoride; 7683-59-2/Isoproterenol; 9007-92-5/Glucagon; EC Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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