| Alterations of pressure waveforms along the coronary arteries and the effect of microcirculatory vasodilation. | |
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MedLine Citation:
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PMID: 16945435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate the differences of pressure waveforms at a distal point of an epicardial coronary artery comparatively to the ostium and to assess the effect of microcirculatory vasodilation on them. BACKGROUND: Pressure waveforms in the systematic circulation and their alterations along the aorta due to wave reflections from the periphery have been extensively studied. However, similar data regarding intracoronary pressure waveforms and the effects of coronary microcirculation on them are limited. METHODS: In 18 patients who underwent diagnostic coronary angiogram or percutaneous coronary intervention in the left circumflex or the right coronary artery, we studied pressure waveforms recorded by a high-fidelity pressure wire, which was advanced to the ostium and to a distal site of the free of significant lesions left anterior descending coronary artery. Pressure recording was performed both at rest and at hyperemia induced by intravenous infusion of adenosine. Analysis of pressure waveforms at the frequency domain was performed with Fast Fourier Transform. RESULTS: At baseline conditions, distal pressure waveforms were characterized by higher pulsatility, higher presystolic wave and higher amplitude of the 11th to the 15th harmonics. Hyperemia increased the pulsatility, compressed the notch and decreased the amplitude of higher than the 10th harmonics of distal waveforms. CONCLUSIONS: This study identifies differences of pressure waveforms between proximal and distal sites of free of significant lesions coronary arteries, which are affected by the status of coronary microcirculation and may therefore facilitate assessment of microvascular disease. |
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Authors:
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Manolis Vavuranakis; Ilias Stamatopoulos; Theodore G Papaioannou; Stavros Nikolopoulos; Konstantinos Toutouzas; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article Date: 2006-08-30 |
Journal Detail:
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Title: International journal of cardiology Volume: 117 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-27 Completed Date: 2007-05-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 254-9 Citation Subset: IM |
Affiliation:
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First Department of Cardiology, Athens Medical School, Hippokratio Hospital, 114 Vasilisis Sofias Ave, Athens 11527, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use Adult Aged Blood Pressure / physiology* Coronary Angiography Coronary Artery Disease / physiopathology* Coronary Circulation / physiology* Coronary Vessels / physiology* Female Humans Hyperemia / physiopathology Male Microcirculation / physiology Middle Aged Pulsatile Flow / physiology Vasodilation / drug effects, physiology* Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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