| Alterations of plasma and cerebrospinal fluid glutamate levels in rats treated with the N-methyl-D-aspartate receptor antagonist, ketamine. | |
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MedLine Citation:
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PMID: 16779778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that the repeated administration of a sub-anesthetic dose of an N-methyl-D-aspartate receptor antagonist, ketamine, can produce an animal model of schizophrenia. Since no information is available on the alterations of the amino acid levels in ketamine-treated rats, we investigated the amino acid composition in the plasma and cerebrospinal fluid of rats that were repeatedly administered with ketamine for 5 consecutive days (30 mg/kg/day). The plasma and cerebrospinal fluid amino acid compositions in the fifth week after cessation of repeated ketamine administration were determined by highperformance liquid chromatography with fluorescence detection using a pre-column fluorescence reagent, i.e. 4-fluoro-7nitro-2,1,3-benzoxadiazole. Among the amino acids investigated in the present study, the level of plasma glutamic acid increased significantly (p < 0.05), while that of the cerebrospinal fluid glutamic acid decreased significantly in the ketamine-treated rats as compared with these levels in control rats injected with saline (p < 0.05, n = 7). These alterations in the glutamic acid level in the plasma and cerebrospinal fluid resemble those in schizophrenic patients, suggesting that ketamine-treated rats may be a useful model for performing research on the pathophysiology of schizophrenia. |
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Authors:
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Masayuki Tomiya; Takeshi Fukushima; Junko Kawai; Chiaki Aoyama; Shogo Mitsuhashi; Tomofumi Santa; Kazuhiro Imai; Toshimasa Toyo'oka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical chromatography : BMC Volume: 20 ISSN: 0269-3879 ISO Abbreviation: Biomed. Chromatogr. Publication Date: 2006 Jun-Jul |
Date Detail:
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Created Date: 2006-06-21 Completed Date: 2006-08-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610241 Medline TA: Biomed Chromatogr Country: England |
Other Details:
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Languages: eng Pagination: 628-33 Citation Subset: IM |
Copyright Information:
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Copyright 2006 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Excitatory Amino Acid Antagonists / pharmacology* Glutamic Acid / blood*, cerebrospinal fluid* Ketamine / pharmacology* Male Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acid Antagonists; 0/Receptors, N-Methyl-D-Aspartate; 56-86-0/Glutamic Acid; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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