Document Detail


Alterations of performance and oxygen utilization in chronically infarcted rat hearts.
MedLine Citation:
PMID:  8729064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progressive dilatation of left ventricle has been demonstrated in hearts post-infarction. However, the relationship of performance and energy consumption in chronically infarcted heart has not been clarified. To address this problem, we measured left ventricular pressure and oxygen consumption (MVO2) during stepwise increases in left ventricular filling volume in isolated isovolumic buffer-perfused rat hearts 8 weeks after let coronary artery ligation or sham-operation. Systolic pressure-volume area (PVA) was calculated as an estimate of total mechanical energy consumed by the heart. The MVO2-PVA relation was analysed to define the economy of the contractile machinery in surviving myocardium. Structural dilatation and reduced pressure generation in infarcted hearts were indicated by a rightward shift of pressure-volume curves and a reduced maximal developed pressure of the left ventricle (80 +/- 5 v 119 +/- 4 mmHg, P < 0.01) which was obtained at substantially higher left ventricular volume compared to control hearts (0.79 +/- 0.02 v 0.39 +/- 0.01 ml, P < 0.01). The slope of the MVO2-PVA relation was significantly lower in the infarcted compared to the control groups (1.02 +/- 0.16 v 1.44 +/- 0.10 10(-5) mlO2/mmHg/ml, P < 0.05), reflecting an increased efficiency of chemomechanical energy transduction in surviving myocardium. However, at the similar MVO2 ventricular pressure development was significantly lower in infarcted hearts due to the unfavorable geometry resulting from ventricular dilatation.
Authors:
R Tian; P Gaudron; S Neubauer; K Hu; G Ertl
Related Documents :
9663534 - Central venous pressure, pulmonary capillary wedge pressure and intrathoracic blood vol...
7353674 - Computing indices of diastolic stiffness has been counterproductive.
8092294 - Influence of acute alterations in cycle length on ventricular function in chick embryos.
6722844 - Inter-institutional variation of systolic time intervals in normal subjects.
8179854 - Vascular structural and functional alterations before and after the development of hype...
22954114 - Efficacy of homemade hemostatics of injected gelatin matrix for immediately treating bl...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  28     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
Affiliation:
Medizinische Universitätsklinik Würzburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Blood Pressure / physiology
Buffers
Chronic Disease
Energy Metabolism / physiology*
Male
Myocardial Infarction / physiopathology*
Myocardial Reperfusion
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Buffers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiac injury by activated leukocytes: effect of cyclooxygenase and lipoxygenase inhibition evaluat...
Next Document:  L-propionylcarnitine enhancement of substrate oxidation and mitochondrial respiration in the diabeti...